Prometrium and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prometrium (progesterone) and Actonel (risedronate sodium). Common drug interactions include deformity among females.

The phase IV clinical study analyzes what interactions people have when they take Prometrium and Actonel. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Prometrium?

Prometrium has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 5,980 Prometrium users. Check the latest studies of Prometrium.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Aug, 01, 2026

86 people who take Prometrium and Actonel together, and have interactions are studied.

Prometrium and Actonel drug interactions.

What are the common drug interactions of Prometrium and Actonel, by gender? *:

female:

Deformity (disfigurement)
Swelling
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Pain
Bone disorder
Loose tooth
Tooth disorder (tooth disease)
Tooth fracture
Nausea (feeling of having an urge to vomit)
Neck pain

male:

n/a

What are the common drug interactions of Prometrium and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Arthralgia (joint pain)
Blood pressure fluctuation
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Muscle spasms (muscle contraction)
Onychoclasis (breaking of the nails)
Pain in extremity
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Blood iron decreased
Contusion (a type of hematoma of tissue in which capillaries)
Deformity (disfigurement)

40-49:

Back pain
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Anxiety
Angiopathy (generic term for a disease of the blood vessels)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bacteraemia (presence of bacteria in the blood)
Blood cholesterol increased
Bone disorder
Bone erosion

50-59:

Jaw fracture
Joint effusion (presence of extra fluid in joint covering)
Loose tooth
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Mitral valve prolapse (heart's mitral valve doesn't work well)
Mucosal inflammation (infection of mucous membrane)
Multiple myeloma (cancer of the plasma cells)
Muscular weakness (muscle weakness)
Neck injury
Oedema peripheral (superficial swelling)

60+:

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Bone disorder
Resorption bone increased
Sensitivity of teeth
Tooth abscess (pus formation in tooth)
Tooth disorder (tooth disease)
Tooth fracture
Toothache (tooth pain)
Abdominal pain upper
Arthralgia (joint pain)

What are the existing conditions these people have? *

High Blood Pressure: 34 people, 39.53%
Multiple Myeloma (cancer of the plasma cells): 20 people, 23.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 20 people, 23.26%
Fatigue (feeling of tiredness): 20 people, 23.26%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 17 people, 19.77%
Joint Pain: 5 people, 5.81%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

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