Prometrium and Botox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prometrium (progesterone) and Botox (botulinum toxin type a). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Prometrium and Botox. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Prometrium?

Prometrium has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 5,980 Prometrium users. Check the latest studies of Prometrium.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,513 Botox users. Check the latest studies of Botox.

On Jul, 21, 2026

25 people who take Prometrium and Botox together, and have interactions are studied.

What are the common drug interactions of Prometrium and Botox, by gender? *:

female:

Headache (pain in head)
Pain
Balance disorder
Blood creatine phosphokinase increased
Compulsive shopping
Constipation
Depression
Dyspnoea (difficult or laboured respiration)
Fall
Hyperaesthesia

male:

n/a

What are the common drug interactions of Prometrium and Botox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthenia (weakness)
Balance disorder
Blood creatine phosphokinase increased
Dyspnoea (difficult or laboured respiration)
Fall
Fatigue (feeling of tiredness)
Headache (pain in head)
Hyperaesthesia
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)

40-49:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Rash generalised (rash on most of body parts)
Therapeutic response decreased (less preventive response)
Back pain
Fibromyalgia (a long-term condition which causes pain all over the body)
Hypokinesia (decreased bodily movement)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain

50-59:

Drug ineffective
Eyelid ptosis (falling of the upper or lower eyelid)
Compulsive shopping
Depression
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Injection site pain
Muscle tightness
Nausea (feeling of having an urge to vomit)

60+:

Agitation (state of anxiety or nervous excitement)
Anxiety
Insomnia (sleeplessness)
Macular hole (small break in the macula, the central area of the retina)
Vision blurred
Vitreous detachment (a condition of the eye in which the vitreous humour separates from the retina)
Drug hypersensitivity
Panic reaction
Somnolence (a state of near-sleep, a strong desire for sleep)
Constipation

What are the existing conditions these people have? *

High Blood Cholesterol: 6 people, 24.00%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 3 people, 12.00%
Skin Wrinkling (wrinkle on skin): 3 people, 12.00%
Headache (pain in head): 3 people, 12.00%
Bipolar Disorder (mood disorder): 3 people, 12.00%
Asthma: 3 people, 12.00%
Weight Loss: 2 people, 8.00%
Vitamin B12 Deficiency: 2 people, 8.00%
Thyroid Diseases: 2 people, 8.00%
Oral Herpes (viral infection of mouth): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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