Prometrium and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prometrium (progesterone) and Keppra (levetiracetam). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Prometrium and Keppra. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Prometrium?

Prometrium has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 5,980 Prometrium users. Check the latest studies of Prometrium.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

21 people who take Prometrium and Keppra together, and have interactions are studied.

Prometrium and Keppra drug interactions.

What are the common drug interactions of Prometrium and Keppra, by gender? *:

female:

Headache (pain in head)
Premature labour
Muscle spasms (muscle contraction)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Migraine (headache)
Abdominal pain
Abdominal pain upper
Acute respiratory failure
Arthralgia (joint pain)

male:

n/a

What are the common drug interactions of Prometrium and Keppra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hospitalisation
Pregnancy

30-39:

Premature labour
Progesterone decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fatigue (feeling of tiredness)
Migraine (headache)
Drug exposure during pregnancy
Headache (pain in head)
Pregnancy
Dizziness
Drug withdrawal convulsions

40-49:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Glossodynia (a burning or painful sensation in the tongue)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Pain
Petit mal epilepsy (absence seizure)

50-59:

Haemorrhage intracranial (bleeding within the skull)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Acute respiratory failure
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Headache (pain in head)

60+:

Abdominal pain
Abdominal pain upper
Haematochezia (passage of stools containing blood)
Headache (pain in head)
Injection site pain
Limb discomfort (discomfort in leg)
Loss of consciousness
Muscle spasms (muscle contraction)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the existing conditions these people have? *

Pain: 6 people, 28.57%
Vaginal Bleeding: 3 people, 14.29%
Nausea (feeling of having an urge to vomit): 3 people, 14.29%
Dehydration (dryness resulting from the removal of water): 3 people, 14.29%
Birth Control: 3 people, 14.29%
Fever: 3 people, 14.29%
Headache (pain in head): 3 people, 14.29%
High Blood Pressure: 3 people, 14.29%
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking): 3 people, 14.29%
Stress And Anxiety: 3 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Prometrium and Keppra?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously