Propacet 100 and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Propacet 100 (acetaminophen; propoxyphene napsylate) and Zide (hydrochlorothiazide). Common drug interactions include tooth abscess among females and injection site pain among males.

The phase IV clinical study analyzes what interactions people have when they take Propacet 100 and Zide. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Propacet 100?

Propacet 100 has active ingredients of acetaminophen; propoxyphene napsylate. eHealthMe is studying from 1,282 Propacet 100 users. Check the latest studies of Propacet 100.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 31, 2026

61 people who take Propacet 100 and Zide together, and have interactions are studied.

Propacet 100 and Zide drug interactions.

What are the common drug interactions of Propacet 100 and Zide, by gender? *:

female:

Tooth abscess (pus formation in tooth)
Uterine cervical squamous metaplasia (non-cancerous changes in the epithelial linings of uterine cervical)
Uterine haemorrhage (uterine bleeding)
Anaemia (lack of blood)
Malignant neoplasm progression (cancer tumour came back)
Surgery
Tooth extraction
Fibula fracture
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Injection site pain
Diarrhoea
Atrioventricular block (heart block)
Cardiomegaly (increased size of heart than normal)
Chest wall pain
Contusion (a type of hematoma of tissue in which capillaries)
Depression
Dizziness
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Propacet 100 and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Drug ineffective
Heart injury
Influenza
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Pneumonia
Respiratory tract infection bacterial
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

50-59:

Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)
Cardiac failure congestive
Conjunctivitis (pink eye)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Hepatitis (inflammation of the liver)
Intermittent claudication
Myalgia (muscle pain)
Oral fungal infection
Panic attack

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture
Disability
Epicondylitis (tennis elbow)
Herpes zoster
Hypercholesterolaemia (high levels of cholesterol in the blood)
Injury
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 21 people, 34.43%
Pain: 11 people, 18.03%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 11 people, 18.03%
Anaemia (lack of blood): 11 people, 18.03%
High Blood Cholesterol: 10 people, 16.39%
Depression: 5 people, 8.20%

* Approximation only. Some reports may have incomplete information.

Do you take Propacet 100 and Zide?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously