Propulsid and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Propulsid (cisapride monohydrate) and Keppra (levetiracetam). Common drug interactions include pain among females and colitis ulcerative among males.

The phase IV clinical study analyzes what interactions people have when they take Propulsid and Keppra. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Propulsid?

Propulsid has active ingredients of cisapride monohydrate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 8,130 Propulsid users. Check the latest studies of Propulsid.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.



On Jul, 28, 2026

18 people who take Propulsid and Keppra together, and have interactions are studied.

Propulsid and Keppra drug interactions.

What are the common drug interactions of Propulsid and Keppra, by gender? *:

female:

  1. Pain
  2. Rhinalgia (pain in the nose)
  3. Sensation of foreign body
  4. Tinnitus (a ringing in the ears)
  5. Balance disorder
  6. Blindness
  7. Dizziness
  8. Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
  9. Neck pain
  10. Nervous system disorder (a general class of medical conditions affecting the nervous system)

male:

  1. Colitis ulcerative (inflammation of colon with ulcer)
  2. Drug ineffective
  3. Petit mal epilepsy (absence seizure)

What are the common drug interactions of Propulsid and Keppra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Drug ineffective
  2. Petit mal epilepsy (absence seizure)

10-19:

n/a

20-29:

  1. Electrocardiogram qt prolonged

30-39:

n/a

40-49:

  1. Syncope (loss of consciousness with an inability to maintain postural tone)
  2. Cervical vertebral fracture
  3. Eructation (release of gas from the digestive tract)
  4. Hypoaesthesia (reduced sense of touch or sensation)
  5. Malignant melanoma (skin cancer rises from melancytes)
  6. Osteosynthesis
  7. Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
  8. Spinal fracture (fracture in one of vertebrae)
  9. Fall
  10. Pubic rami fracture

50-59:

  1. Colitis ulcerative (inflammation of colon with ulcer)

60+:

  1. Dysphagia (a condition in which swallowing is difficult or painful)
  2. Tardive dyskinesia (a disorder that involves involuntary movements)
  3. Tinnitus (a ringing in the ears)
  4. Balance disorder
  5. Blindness
  6. Dizziness
  7. Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
  8. Neck pain
  9. Nervous system disorder (a general class of medical conditions affecting the nervous system)
  10. Postnasal drip

What are the existing conditions these people have? *

  1. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 11.11%
  2. Pain: 1 person, 5.56%
  3. Multiple Allergies (allergy to multiple agents): 1 person, 5.56%
  4. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 5.56%
  5. Hypersensitivity: 1 person, 5.56%
  6. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 1 person, 5.56%
  7. Gastrointestinal Motility Disorder (abnormal intestinal contractions): 1 person, 5.56%
  8. Gastric Haemorrhage (bleeding stomach): 1 person, 5.56%
  9. Fungal Infection: 1 person, 5.56%
  10. Dyspnea (difficult or laboured breathing): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Propulsid and Keppra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Propulsid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Keppra:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Propulsid and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Keppra and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on cisapride monohydrate and levetiracetam (the active ingredients of Propulsid and Keppra, respectively), and Propulsid and Keppra (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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