Protonix and Actifed drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protonix (pantoprazole sodium) and Actifed (pseudoephedrine hydrochloride; triprolidine hydrochloride). Common drug interactions include chronic kidney disease among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Protonix and Actifed. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Actifed?

Actifed has active ingredients of pseudoephedrine hydrochloride; triprolidine hydrochloride. It is often used in allergies. eHealthMe is studying from 1,091 Actifed users. Check the latest studies of Actifed.

On Jul, 25, 2026

18 people who take Protonix and Actifed together, and have interactions are studied.

What are the common drug interactions of Protonix and Actifed, by gender? *:

female:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal impairment (severely reduced kidney function)
Headache (pain in head)
Asthenia (weakness)
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Malaise (a feeling of general discomfort or uneasiness)
Adjustment disorder with mixed anxiety and depressed mood

male:

Abdominal pain
Drug ineffective
Hypotension (abnormally low blood pressure)
Injury
Overdose
Pain
Staphylococcal infection (an infection with staphylococcus bacteria)
Suicide attempt
Abdominal discomfort
Haemoglobin decreased

What are the common drug interactions of Protonix and Actifed, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal impairment (severely reduced kidney function)
Asthenia (weakness)
Fatigue (feeling of tiredness)
Joint swelling
Lethargy (tiredness)
Oedema peripheral (superficial swelling)

60+:

Abdominal discomfort
Dyspepsia (indigestion)
Nausea (feeling of having an urge to vomit)
Haemoglobin decreased
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Monoclonal immunoglobulin present
Platelet count decreased
White blood cell count decreased
Drug hypersensitivity

What are the existing conditions these people have? *

Pain: 10 people, 55.56%
Depression: 7 people, 38.89%
Thyroid Diseases: 6 people, 33.33%
Hypersensitivity: 6 people, 33.33%
Stress And Anxiety: 6 people, 33.33%
Cardiac Disorder: 6 people, 33.33%
Fever: 6 people, 33.33%
Gastritis (inflammation of stomach): 6 people, 33.33%
Nausea (feeling of having an urge to vomit): 6 people, 33.33%
Nasopharyngitis (inflammation of the nasopharynx): 6 people, 33.33%

* Approximation only. Some reports may have incomplete information.

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