Protonix and Codeine sulfate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protonix (pantoprazole sodium) and Codeine sulfate (codeine sulfate). Common drug interactions include osteoarthritis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Protonix and Codeine sulfate. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Codeine sulfate?

Codeine sulfate has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 4,510 Codeine sulfate users. Check the latest studies of Codeine sulfate.

On Jul, 28, 2026

67 people who take Protonix and Codeine sulfate together, and have interactions are studied.

Protonix and Codeine sulfate drug interactions.

What are the common drug interactions of Protonix and Codeine Sulfate, by gender? *:

female:

Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Abscess neck (neck abscesses)
Abscess oral (abscess in the mouth)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Apical granuloma (tumour of the apex of a nonvital tooth)
Asthma
Bipolar disorder (mood disorder)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone loss
Deformity (disfigurement)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Alanine aminotransferase decreased
Albumin globulin ratio decreased
Anion gap increased
Aspartate aminotransferase decreased
Aspartate aminotransferase increased
Asthenia (weakness)
Blood albumin decreased
Blood alkaline phosphatase increased

What are the common drug interactions of Protonix and Codeine Sulfate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Cardiac arrest
Drug hypersensitivity
Emotional distress
Fear of disease
Gallbladder non-functioning
Hepatic failure (liver failure)
Injury
Nausea (feeling of having an urge to vomit)
Non-alcoholic steatohepatitis (liver inflammation caused by a build up of fat in the liver)

40-49:

Anxiety
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Vomiting
Weight decreased
Fluid retention (an abnormal accumulation of fluid in the blood)
Haematemesis (vomiting of blood)

50-59:

Bone disorder
Compression fracture (fracture due to pressure caused by injury)
Cystocele (a condition that occurs when the tough fibrous wall between a woman's bladder and her vagina is torn by childbirth)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Dyspnoea (difficult or laboured respiration)
Enterocele (hernia of the intestine through the vagina)
Facial pain
Fall
Febrile neutropenia (fever with reduced white blood cells)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hypotension (abnormally low blood pressure)
Cardiac valve disease (heart valve disease)
Chronic kidney disease
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)
Restlessness (not able to rest)
Unresponsive to stimuli

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 11 people, 16.42%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 10 people, 14.93%
Depression: 9 people, 13.43%
Breast Cancer: 7 people, 10.45%
Stress And Anxiety: 6 people, 8.96%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 5 people, 7.46%
Metastases To Spine (cancer spreads to spine): 5 people, 7.46%
Metastases To Bone (cancer spreads to bone): 5 people, 7.46%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 5 people, 7.46%
Asthma: 5 people, 7.46%

* Approximation only. Some reports may have incomplete information.

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