Protonix and Ontak drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protonix (pantoprazole sodium) and Ontak (denileukin diftitox). Common drug interactions include acute graft versus host disease in intestine among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Protonix and Ontak. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Ontak?

Ontak has active ingredients of denileukin diftitox. eHealthMe is studying from 457 Ontak users. Check the latest studies of Ontak.

On Jul, 09, 2026

18 people who take Protonix and Ontak together, and have interactions are studied.

What are the common drug interactions of Protonix and Ontak, by gender? *:

female:

Acute graft versus host disease in intestine (acute complication in intestine following an allogeneic tissue/blood transplant)
Neoplasm malignant (cancer tumour)
Pyrexia (fever)
Cerebral haemorrhage (bleeding within the brain)
Diarrhoea
Hypertension (high blood pressure)
Intraventricular haemorrhage (intraventricular bleeding)
Nausea (feeling of having an urge to vomit)
Renal cell carcinoma (a kidney cancer)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)

male:

Dyspnoea (difficult or laboured respiration)
Actinic keratosis (skin disease due to sun exposure)
Peripheral t-cell lymphoma unspecified (peripheral t-cell cancer unspecified)
Pyoderma (any skin disease that is pyogenic)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abasia (inability to walk)
Death
Decreased appetite
General physical health deterioration (weak health status)
Lung neoplasm malignant (cancer tumour of lung)

What are the common drug interactions of Protonix and Ontak, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cerebral haemorrhage (bleeding within the brain)
Hypertension (high blood pressure)
Intraventricular haemorrhage (intraventricular bleeding)
Scotoma (an area of diminished vision within the visual field)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Vision blurred

40-49:

Actinic keratosis (skin disease due to sun exposure)
Acute respiratory failure
Asthenia (weakness)
Blood albumin decreased
Blood calcium decreased
Confusional state
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Oedema peripheral (superficial swelling)
Pain

50-59:

n/a

60+:

Leukopenia (less number of white blood cells in blood)
Neoplasm malignant (cancer tumour)
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Pyrexia (fever)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Renal cell carcinoma (a kidney cancer)

What are the existing conditions these people have? *

Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 5 people, 27.78%
Constipation: 4 people, 22.22%
High Blood Pressure: 4 people, 22.22%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 3 people, 16.67%
T-Cell Lymphoma (a blood cell cancer): 2 people, 11.11%
Pain: 2 people, 11.11%
Ovarian Cancer Metastatic (cancer of ovary spreads to other organ or parts): 2 people, 11.11%
Non-Small Cell Lung Cancer Stage Iv: 2 people, 11.11%
Nausea And Vomiting: 2 people, 11.11%
Nausea (feeling of having an urge to vomit): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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