Protonix and Optivar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protonix (pantoprazole sodium) and Optivar (azelastine hydrochloride). Common drug interactions include chronic obstructive pulmonary disease among females and balance disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Protonix and Optivar. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Optivar?

Optivar has active ingredients of azelastine hydrochloride. eHealthMe is studying from 367 Optivar users. Check the latest studies of Optivar.

On Jul, 19, 2026

30 people who take Protonix and Optivar together, and have interactions are studied.

What are the common drug interactions of Protonix and Optivar, by gender? *:

female:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Depression
Impaired healing
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Nausea (feeling of having an urge to vomit)
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Abdominal distension

male:

Balance disorder
Hypoaesthesia (reduced sense of touch or sensation)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain
Bone cyst
Bone disorder
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Calculus urinary (stone in urinary system)
Cardiac failure congestive

What are the common drug interactions of Protonix and Optivar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abscess (pus)
Activities of daily living impaired
Agitation (state of anxiety or nervous excitement)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arrhythmia (irregular heartbeat)
Arteriosclerosis (thickening and hardening of arteries)
Arthropathy
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Back pain

40-49:

Anxiety
Insomnia (sleeplessness)
Depression
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Age-related macular degeneration
Alopecia (absence of hair from areas of the body)
Anaphylactic reaction (serious allergic reaction)
Blood glucose increased
Diplopia (double vision)
Headache (pain in head)

50-59:

Hypoaesthesia (reduced sense of touch or sensation)
Impaired self-care
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Pain
Chronic kidney disease
Renal failure (kidney dysfunction)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Abdominal distension
Balance disorder
Emotional distress

60+:

Abscess (pus)
Activities of daily living impaired
Balance disorder
Bone cyst
Bone disorder
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Calculus urinary (stone in urinary system)
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)

What are the existing conditions these people have? *

Muscle Spasms (muscle contraction): 11 people, 36.67%
Depression: 8 people, 26.67%
Toothaches (tooth pain): 7 people, 23.33%
High Blood Pressure: 5 people, 16.67%
Anaemia (lack of blood): 4 people, 13.33%
Asthma: 4 people, 13.33%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 10.00%
Bladder Pain: 3 people, 10.00%
Bladder Spasm: 3 people, 10.00%
Bone Neoplasm Malignant (cancer of bone): 3 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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