Protonix and Tykerb drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protonix (pantoprazole sodium) and Tykerb (lapatinib ditosylate). Common drug interactions include paraesthesia among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Protonix and Tykerb. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

On Jul, 21, 2026

88 people who take Protonix and Tykerb together, and have interactions are studied.

What are the common drug interactions of Protonix and Tykerb, by gender? *:

female:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pyrexia (fever)
Dry skin
Pain
Decreased appetite
Dizziness
Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Weight decreased
Constipation

male:

Anxiety
Infection
Spinal haemangioma (an abnormal, but non cancer blood vessel tumour that commonly occurs in the spine)
Aortic valve incompetence
Arthralgia (joint pain)
Back pain
Diastolic dysfunction
Dizziness
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Protonix and Tykerb, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Abdominal pain upper
Abdominal tenderness
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic calcification (aortic calcification sign of heart valve disease)
Aortic valve sclerosis (narrowing of the aortic valve)

20-29:

n/a

30-39:

Infection
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Anal fissure
Anogenital warts
Anxiety
Bacterial infection
Bone erosion

40-49:

Diarrhoea
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Dizziness
Rash
Vomiting
Abdominal pain upper
Anxiety
Constipation
Dry skin

50-59:

Abdominal pain upper
Anxiety
Asthenia (weakness)
Back pain
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Dehydration (dryness resulting from the removal of water)
Dizziness
Fall
Gingival pain (gum pain)

60+:

Diarrhoea
Fatigue (feeling of tiredness)
Decreased appetite
Chest pain
Mitral valve incompetence (inefficient heart valve)
Pain in jaw
Retching (strong involuntary effort to vomit)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tricuspid valve incompetence (inefficient heart valve)
Asthenia (weakness)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 11 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and Tykerb?

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