Protonix and Tymlos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protonix (pantoprazole sodium) and Tymlos (abaloparatide). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Protonix and Tymlos. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Tymlos?

Tymlos has active ingredients of abaloparatide. eHealthMe is studying from 16,516 Tymlos users. Check the latest studies of Tymlos.



On Jul, 13, 2026

36 people who take Protonix and Tymlos together, and have interactions are studied.

Protonix and Tymlos drug interactions.

What are the common drug interactions of Protonix and Tymlos, by gender? *:

female:

  1. Headache (pain in head)
  2. Osteoporosis (bones weak and more likely to break)
  3. Emotional distress
  4. Femur fracture
  5. Hip fracture
  6. Mobility decreased (ability to move is reduced)
  7. Nephrolithiasis (calculi in the kidneys)
  8. Pelvic fracture
  9. Ulcer haemorrhage (bleeding ulcer)
  10. Upper limb fracture

male:

n/a

What are the common drug interactions of Protonix and Tymlos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Bone density decreased
  4. Chronic kidney disease
  5. Decreased activity
  6. Depression
  7. Emotional distress
  8. Femur fracture
  9. Hip fracture
  10. Mobility decreased (ability to move is reduced)

50-59:

  1. Back pain
  2. Muscle spasms (muscle contraction)
  3. Abdominal discomfort
  4. Agitation (state of anxiety or nervous excitement)
  5. Dyskinesia (abnormality or impairment of voluntary movement)
  6. Headache (pain in head)
  7. Heart rate increased
  8. Hypoacusis (loss of hearing)
  9. Throat tightness

60+:

  1. Nausea (feeling of having an urge to vomit)
  2. Headache (pain in head)
  3. Fatigue (feeling of tiredness)
  4. Inflammatory bowel disease
  5. Influenza
  6. Irritable bowel syndrome
  7. Osteoporosis (bones weak and more likely to break)
  8. Palpitations (feelings or sensations that your heart is pounding or racing)
  9. Psoriasis (immune-mediated disease that affects the skin)
  10. Weight increased

What are the existing conditions these people have? *

  1. Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 16 people, 44.44%
  2. Osteoporosis (bones weak and more likely to break): 11 people, 30.56%
  3. Senile Osteoporosis (weak bones with ageing): 3 people, 8.33%
  4. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 8.33%
  5. Psoriasis (immune-mediated disease that affects the skin): 3 people, 8.33%
  6. Seasonal Allergy (allergic condition due to certain season): 2 people, 5.56%
  7. Irritable Bowel Syndrome: 2 people, 5.56%
  8. Insomnia (sleeplessness): 2 people, 5.56%
  9. Hepatitis B: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and Tymlos?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Protonix and Tymlos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tymlos:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Protonix and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tymlos and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium and abaloparatide (the active ingredients of Protonix and Tymlos, respectively), and Protonix and Tymlos (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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