Protonix and Vortioxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protonix (pantoprazole sodium) and Vortioxetine (vortioxetine). Common drug interactions include renal injury among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Protonix and Vortioxetine. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,659 Protonix users. Check the latest studies of Protonix.

What is Vortioxetine?

Vortioxetine has active ingredients of vortioxetine. eHealthMe is studying from 2,440 Vortioxetine users. Check the latest studies of Vortioxetine.

On Aug, 02, 2026

12 people who take Protonix and Vortioxetine together, and have interactions are studied.

Protonix and Vortioxetine drug interactions.

What are the common drug interactions of Protonix and Vortioxetine, by gender? *:

female:

Renal injury (kidney injury)
Depression
Renal tubular necrosis (death of kidney tubules)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abnormal sleep-related event
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Gingival pain (gum pain)
Hepatitis (inflammation of the liver)
Hypercapnia (too much smoke)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Agitation (state of anxiety or nervous excitement)
Decreased appetite
Nausea (feeling of having an urge to vomit)
Nervousness
Weight decreased

What are the common drug interactions of Protonix and Vortioxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Sepsis (a severe blood infection that can lead to organ failure and death)
Injection site pain

50-59:

Abnormal sleep-related event
Dyspnoea (difficult or laboured respiration)
Hypercapnia (too much smoke)
Night sweats (sweating in night)
Nightmare (unpleasant dream)
Pyromania (irresistible urge to start fires)
Sleep terror (felling of terror in sleep)
Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Diarrhoea
Gingival pain (gum pain)
Hepatitis (inflammation of the liver)

What are the existing conditions these people have? *

Depression: 7 people, 58.33%
High Blood Pressure: 5 people, 41.67%
High Blood Cholesterol: 5 people, 41.67%
Pain: 5 people, 41.67%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 4 people, 33.33%
Renal Disorder (kidney disease): 4 people, 33.33%
Indigestion: 4 people, 33.33%
Asthma: 3 people, 25.00%
Stress And Anxiety: 3 people, 25.00%
Nausea (feeling of having an urge to vomit): 3 people, 25.00%

* Approximation only. Some reports may have incomplete information.

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