Protopic and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protopic (tacrolimus) and Aldactone (spironolactone). Common drug interactions include post procedural haemorrhage among females and mitral valve incompetence among males.

The phase IV clinical study analyzes what interactions people have when they take Protopic and Aldactone. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Protopic?

Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Jul, 04, 2026

23 people who take Protopic and Aldactone together, and have interactions are studied.

Protopic and Aldactone drug interactions.

What are the common drug interactions of Protopic and Aldactone, by gender? *:

female:

Post procedural haemorrhage (post procedural bleeding)
Acute respiratory failure
Alanine aminotransferase increased
Aspartate aminotransferase increased
Atrioventricular block (heart block)
Bile duct stone
Death
Diarrhoea
Disease progression
Failure to thrive (inadequate weight gain and physical growth in children)

male:

Mitral valve incompetence (inefficient heart valve)
Dyspnoea (difficult or laboured respiration)
Eye pruritus (eye itching)
Eye swelling
Fatigue (feeling of tiredness)
Haemoglobin decreased
Hypertensive heart disease
Laryngeal oedema (swelling of larynx)
Lung disorder (lung disease)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Protopic and Aldactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Failure to thrive (inadequate weight gain and physical growth in children)

10-19:

Infarction (obstruction of the blood supply to an organ or region of tissue)
Mitral valve incompetence (inefficient heart valve)
Pericardial effusion (fluid around the heart)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

20-29:

n/a

30-39:

Headache (pain in head)
Intestinal haemorrhage (bleeding from intestine)
Post procedural haemorrhage (post procedural bleeding)

40-49:

Bradycardia (abnormally slow heart action)
Dizziness
Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Oedema (fluid collection in tissue)
Hypokalaemia (low potassium)
Iron deficiency anaemia
Pain in extremity
Atrioventricular block (heart block)
Bile duct stone

50-59:

Laryngeal oedema (swelling of larynx)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Throat irritation
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood potassium increased
C-reactive protein increased
Chills (felling of cold)
Death
Fatigue (feeling of tiredness)

60+:

Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Acute respiratory failure
Disease progression

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 11 people, 47.83%
Insomnia (sleeplessness): 7 people, 30.43%
Itching: 6 people, 26.09%
Cardiac Failure: 5 people, 21.74%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 5 people, 21.74%
Gastritis (inflammation of stomach): 5 people, 21.74%
Diabetes: 5 people, 21.74%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 5 people, 21.74%
Ascites (accumulation of fluid in the abdominal cavity): 4 people, 17.39%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 4 people, 17.39%

* Approximation only. Some reports may have incomplete information.

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