Protopic and Cytoxan drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Protopic (tacrolimus) and Cytoxan (cyclophosphamide). Common drug interactions include alopecia among females and anaemia among males.
The phase IV clinical study analyzes what interactions people have when they take Protopic and Cytoxan. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.
What is Protopic?
Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.
What is Cytoxan?
Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.
28 people who take Protopic and Cytoxan together, and have interactions are studied.

What are the common drug interactions of Protopic and Cytoxan, by gender? *:
female:
- Alopecia (absence of hair from areas of the body)
- Conjunctivitis (pink eye)
- Erythema of eyelid (redness of the eyelid)
- Eyelid oedema (eyelids are swollen and contain excessive fluid)
- Haemorrhoids (a swollen vein or group of veins in the region of the anus)
- Neck pain
- Osteoarthritis (a joint disease caused by cartilage loss in a joint)
- Exostosis (formation of new bone on the surface of a bone)
- Hepatic lesion
- Hypersensitivity
male:
- Anaemia (lack of blood)
- Dizziness
- Heart rate irregular
- Vomiting
- Anxiety
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Hodgkin's disease (cancer originating from white blood cells)
- Night sweats (sweating in night)
- Oral disorder (mouth disease)
- Oropharyngeal pain
What are the common drug interactions of Protopic and Cytoxan, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Anaemia (lack of blood)
- Anxiety
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Dizziness
- Fall
- Fatigue (feeling of tiredness)
- Febrile neutropenia (fever with reduced white blood cells)
- Headache (pain in head)
- Hodgkin's disease (cancer originating from white blood cells)
- Nausea (feeling of having an urge to vomit)
30-39:
- Anaemia (lack of blood)
- Breast cancer female
- Intervertebral disc protrusion (spinal disc protrusion)
- Osteopenia (a condition where bone mineral density is lower than normal)
- Ovarian cyst (fluid filled sac of the ovary)
- Acne (skin problems that cause pimples)
- Alopecia (absence of hair from areas of the body)
- Conjunctivitis (pink eye)
- Erythema of eyelid (redness of the eyelid)
- Eyelid oedema (eyelids are swollen and contain excessive fluid)
40-49:
- Upper limb fracture
- Vitamin d deficiency
- Vomiting
- Weight decreased
- Dizziness
- Alpha 1 foetoprotein increased
- Amyloidosis (a tumour within which amyloid is produced)
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
- Anuria (failure of the kidneys to produce urine)
- Anxiety
50-59:
n/a
60+:
- Abdominal pain
- Abdominal pain upper
- Cellulitis (infection under the skin)
- Cervicobrachial syndrome (pain in neck and arm with changing location)
- Concussion (short loss of normal brain function in response to a head injury)
- Constipation
- Contusion (a type of hematoma of tissue in which capillaries)
- Diarrhoea
- Disease recurrence
- Dizziness
What are the existing conditions these people have? *
- Vitiligo (pigment is lost from areas of the skin): 12 people, 42.86%
- Pain: 3 people, 10.71%
- Bipolar Disorder (mood disorder): 3 people, 10.71%
- Stress And Anxiety: 2 people, 7.14%
- Nausea And Vomiting: 2 people, 7.14%
- Nausea (feeling of having an urge to vomit): 2 people, 7.14%
- Gastric Ph Decreased: 2 people, 7.14%
- Gastric Disorder (disease of stomach): 2 people, 7.14%
* Approximation only. Some reports may have incomplete information.
Do you take Protopic and Cytoxan?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Protopic and Cytoxan:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Protopic:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Cytoxan:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Protopic and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Cytoxan and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
- Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
How the study uses the data?
The study uses data from the FDA. It is based on tacrolimus and cyclophosphamide (the active ingredients of Protopic and Cytoxan, respectively), and Protopic and Cytoxan (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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