Protopic and Fluocinonide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protopic (tacrolimus) and Fluocinonide (fluocinonide). Common drug interactions include breast cancer among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Protopic and Fluocinonide. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Protopic?

Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.

What is Fluocinonide?

Fluocinonide has active ingredients of fluocinonide. It is often used in eczema. eHealthMe is studying from 6,385 Fluocinonide users. Check the latest studies of Fluocinonide.

On Aug, 11, 2026

87 people who take Protopic and Fluocinonide together, and have interactions are studied.

Protopic and Fluocinonide drug interactions.

What are the common drug interactions of Protopic and Fluocinonide, by gender? *:

female:

Breast cancer
Dry eye (lack of adequate tears)
Dry skin
Insomnia (sleeplessness)
Skin burning sensation
Skin cancer
Anxiety
Chronic kidney disease
Infection
Nasal dryness (dry nose)

male:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Corneal abrasion (loss of the surface of cornea)
Disturbance in attention
Foreign body in eye (foreign particle in eye)
Joint dislocation (a joint position is changed from normal position)
Oesophagitis (inflammation of oesophagus)
Painful respiration
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)

What are the common drug interactions of Protopic and Fluocinonide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Asthma
Bone marrow failure
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Diarrhoea

10-19:

Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Erythema (redness of the skin)
Hypersensitivity
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Nasopharyngitis (inflammation of the nasopharynx)
Oligomenorrhoea (infrequent (or, in occasional usage, very light) menstruation)
Overdose
Pruritus (severe itching of the skin)
Pyrexia (fever)

20-29:

Rash
Fatigue (feeling of tiredness)
Lymphadenopathy (disease or enlargement of lymph nodes)
Pruritus (severe itching of the skin)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Chest pain
Corneal abrasion (loss of the surface of cornea)
Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Foreign body in eye (foreign particle in eye)

30-39:

Rash
Anxiety
Back pain
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Drug toxicity
Dry skin
Ear pain
Gynaecomastia (enlargement of the gland tissue of the male breast)
Hodgkin's disease (cancer originating from white blood cells)
Hypersensitivity

40-49:

Rash
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Discomfort
Nasal dryness (dry nose)
Therapeutic response decreased (less preventive response)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Drug ineffective
Ear pain
Erythema (redness of the skin)
Eye inflammation

50-59:

Renal disorder (kidney disease)
Renal failure (kidney dysfunction)
Skin burning sensation
Skin discomfort (skin pain/irritation)
Therapeutic response decreased (less preventive response)
Anxiety
Arthralgia (joint pain)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Depressed mood
Exophthalmos (bulging or protruding eyeball)

60+:

Erythema (redness of the skin)
Hypertension (high blood pressure)
Ataxia (loss of full control of bodily movements)
Back pain
Body tinea (ringworm of the body)
Bone marrow failure
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Cellulitis (infection under the skin)
Cervicobrachial syndrome (pain in neck and arm with changing location)
Concussion (short loss of normal brain function in response to a head injury)

What are the existing conditions these people have? *

Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 25 people, 28.74%
Psoriasis (immune-mediated disease that affects the skin): 13 people, 14.94%
Pain: 8 people, 9.20%
Rashes (redness): 6 people, 6.90%
High Blood Pressure: 5 people, 5.75%
High Blood Cholesterol: 5 people, 5.75%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.75%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 5.75%

* Approximation only. Some reports may have incomplete information.

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