Protopic and Temaz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Protopic (tacrolimus) and Temaz (temazepam). Common drug interactions include dyskinesia among females and depressed level of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Protopic and Temaz. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Protopic?

Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.

What is Temaz?

Temaz has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 42,293 Temaz users. Check the latest studies of Temaz.

On Jul, 17, 2026

28 people who take Protopic and Temaz together, and have interactions are studied.

What are the common drug interactions of Protopic and Temaz, by gender? *:

female:

Dyskinesia (abnormality or impairment of voluntary movement)
Dyspepsia (indigestion)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dysthymic disorder (mild chronic depression disorder)
Emotional distress
Essential hypertension (primary hypertension)
Excessive eye blinking (excessive blinking is dry eyes)
External ear cellulitis (outer ear skin infection)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Eye haemorrhage (bleeding in the eye)

male:

Depressed level of consciousness
Drug level increased
Diarrhoea
Fall
Grip strength decreased
Impaired driving ability
Limb discomfort (discomfort in leg)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sinusitis (inflammation of sinus)
Therapeutic response unexpected

What are the common drug interactions of Protopic and Temaz, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Agitation (state of anxiety or nervous excitement)
Blood pressure increased
Eye swelling
Intentional self-injury
Visual impairment

40-49:

Depressed level of consciousness
Drug level increased
Hallucination (an experience involving the perception of something not present)
Hepatic failure (liver failure)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Psychotic disorder
Confusional state
Eye haemorrhage (bleeding in the eye)
Influenza

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal disorder (kidney disease)
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Essential hypertension (primary hypertension)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatitis c
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal impairment (severely reduced kidney function)

60+:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Heart rate decreased
Impaired driving ability
Limb discomfort (discomfort in leg)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Sinusitis (inflammation of sinus)
Therapeutic response unexpected
Tremor (trembling or shaking movements in one or more parts of your body)
Urinary tract infection
Visual impairment

What are the existing conditions these people have? *

Asthma: 6 people, 21.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 17.86%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 17.86%
Depression: 4 people, 14.29%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 14.29%
Pain: 4 people, 14.29%
Stress And Anxiety: 3 people, 10.71%
High Blood Pressure: 3 people, 10.71%
Constipation: 2 people, 7.14%
Cough: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Protopic and Temaz?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously