Provera and Estinyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provera (medroxyprogesterone acetate) and Estinyl (ethinyl estradiol). Common drug interactions include breast cancer among females and alopecia among males.

The phase IV clinical study analyzes what interactions people have when they take Provera and Estinyl. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

What is Estinyl?

Estinyl has active ingredients of ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 133 Estinyl users. Check the latest studies of Estinyl.

On Jul, 13, 2026

62 people who take Provera and Estinyl together, and have interactions are studied.

What are the common drug interactions of Provera and Estinyl, by gender? *:

female:

Breast cancer
Breast disorder
Breast cancer female
Contralateral breast cancer (cancer of breast opposite side)
Endometrial cancer
Breast cancer in situ
Oestrogen receptor assay positive
Breast cancer metastatic
Dyspnoea (difficult or laboured respiration)
Progesterone receptor assay positive

male:

Alopecia (absence of hair from areas of the body)
Blood testosterone increased
Libido decreased (loss of interest in sex)
Temporal lobe epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe)
Breast discharge
Breast tenderness
Crying
Cushing's syndrome (obesity, a rounded face, increased fat)
Emotional disorder
Gynaecomastia (enlargement of the gland tissue of the male breast)

What are the common drug interactions of Provera and Estinyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alopecia (absence of hair from areas of the body)
Blood testosterone increased
Breast discharge
Breast tenderness
Crying
Cushing's syndrome (obesity, a rounded face, increased fat)
Depression
Emotional disorder
Gynaecomastia (enlargement of the gland tissue of the male breast)
Hypertrophy breast (increase in the volume of breast due to the enlargement of its component cells)

40-49:

Breast cancer metastatic
Breast disorder
Breast cancer
Malignant neoplasm progression (cancer tumour came back)

50-59:

Breast cancer
Contralateral breast cancer (cancer of breast opposite side)
Uterine cancer
Breast disorder
Deep venous thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dyspnoea (difficult or laboured respiration)
Oxygen saturation decreased
Pulmonary embolism (blockage of the main artery of the lung)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cutaneous lupus erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms)

60+:

Breast cancer
Endometrial cancer
Breast cancer metastatic
Chest pain
Confusion
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Diarrhoea
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)

* Approximation only. Some reports may have incomplete information.

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