Provera and Zelnorm drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provera (medroxyprogesterone acetate) and Zelnorm (tegaserod maleate). Common drug interactions include depression among females.

The phase IV clinical study analyzes what interactions people have when they take Provera and Zelnorm. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

On Jul, 16, 2026

38 people who take Provera and Zelnorm together, and have interactions are studied.

What are the common drug interactions of Provera and Zelnorm, by gender? *:

female:

Depression
Dyspepsia (indigestion)
Diarrhoea
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Irritable bowel syndrome
Fatigue (feeling of tiredness)
Metrorrhagia (uterine bleeding at irregular intervals)
Palpitations (feelings or sensations that your heart is pounding or racing)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))

male:

n/a

What are the common drug interactions of Provera and Zelnorm, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Femoral neck fracture (neck of femur bone fracture)
Metrorrhagia (uterine bleeding at irregular intervals)
Abdominal pain
Angle closure glaucoma (term used for several ocular diseases that ultimately result in increased intraocular pressure (iop) and decreased visual acuity)
Cholecystitis chronic (long lasting infection of gallbladder)
Confusional state
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Hyporeflexia (a condition of below normal or absent reflexes)
Nausea (feeling of having an urge to vomit)

30-39:

Anxiety
Agitation (state of anxiety or nervous excitement)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Decreased appetite
Difficulty in walking
Dysarthria (speech disorder)
Muscle spasms (muscle contraction)
Pain
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal distension

40-49:

Blood pressure decreased
Bradycardia (abnormally slow heart action)
Breath sounds
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Cardiac flutter (abnormal heart rhythm)
Cardiomegaly (increased size of heart than normal)
Cerebral haemorrhage (bleeding within the brain)
Chest discomfort
Chest pain
Choking (mechanical obstruction of the flow of air from the environment into the lungs)

50-59:

Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Weight increased
Abdominal distension
Anogenital warts
Anxiety
Asthma exercise induced
Breast cancer
Breast swelling

60+:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Constipation
Dyspepsia (indigestion)
Flatulence (flatus expelled through the anus)
Irritability
Tinnitus (a ringing in the ears)

What are the existing conditions these people have? *

Irritable Bowel Syndrome: 16 people, 42.11%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.26%
Pain: 2 people, 5.26%
Breast Pain: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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