Provigil and Amerge drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provigil (modafinil) and Amerge (naratriptan hydrochloride). Common drug interactions include flushing among females.

The phase IV clinical study analyzes what interactions people have when they take Provigil and Amerge. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

What is Amerge?

Amerge has active ingredients of naratriptan hydrochloride. It is often used in migraine. eHealthMe is studying from 1,470 Amerge users. Check the latest studies of Amerge.

On Jul, 21, 2026

32 people who take Provigil and Amerge together, and have interactions are studied.

What are the common drug interactions of Provigil and Amerge, by gender? *:

female:

Flushing (the warm, red condition of human skin)
Headache (pain in head)
Bipolar disorder (mood disorder)
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Csf volume increased
Drug hypersensitivity
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Feeling hot

male:

n/a

What are the common drug interactions of Provigil and Amerge, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Csf volume increased
Depression
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Feeling hot
Flushing (the warm, red condition of human skin)
Food allergy
Food craving
Gastric disorder (disease of stomach)

40-49:

Hemiparesis (weakness on one side of the body)
Intervertebral disc disorder (spinal disc disorder)
Intervertebral disc protrusion (spinal disc protrusion)
Ligament sprain (ligament stretched)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myalgia (muscle pain)
Neck pain
Nerve compression
Neuralgia (pain in one or more nerves)

50-59:

Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Blood pressure increased

60+:

n/a

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 15.62%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 12.50%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 9.38%
Sleep Disorder: 2 people, 6.25%
Oral Herpes (viral infection of mouth): 2 people, 6.25%
Hypersensitivity: 2 people, 6.25%
Headache (pain in head): 2 people, 6.25%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 6.25%
Depression: 2 people, 6.25%
Circadian Rhythm Sleep Disorder (family of sleep disorders affecting, among other things, the timing of sleep): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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