Provigil and Fluocinonide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provigil (modafinil) and Fluocinonide (fluocinonide). Common drug interactions include aortic valve incompetence among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Provigil and Fluocinonide. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

What is Fluocinonide?

Fluocinonide has active ingredients of fluocinonide. It is often used in eczema. eHealthMe is studying from 6,385 Fluocinonide users. Check the latest studies of Fluocinonide.

On Jul, 08, 2026

68 people who take Provigil and Fluocinonide together, and have interactions are studied.

Provigil and Fluocinonide drug interactions.

What are the common drug interactions of Provigil and Fluocinonide, by gender? *:

female:

Aortic valve incompetence
Aortic valve sclerosis (narrowing of the aortic valve)
Aortic valve stenosis (narrowing of the aortic valve)
Blood glucose increased
Breast hyperplasia (accumulation of abnormal cells in a breast duct)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac flutter (abnormal heart rhythm)
Cardioactive drug level decreased
Colitis (inflammation of colon)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

male:

Depression
Hypotension (abnormally low blood pressure)
Oedema (fluid collection in tissue)
Rash
Swelling
Weight decreased
Cardiac disorder
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Acarodermatitis (skin inflammation caused by mites (acarids))
Dry skin

What are the common drug interactions of Provigil and Fluocinonide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypertension (high blood pressure)
Surgery

20-29:

Anxiety
Chest discomfort
Crying
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Disturbance in attention
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fear
Hypoaesthesia (reduced sense of touch or sensation)

30-39:

Decreased appetite
Dizziness
Heart rate increased
Hypertension (high blood pressure)
Restless legs syndrome (a powerful urge to move your legs)
Stress
Anxiety
Palpitations (feelings or sensations that your heart is pounding or racing)
Precancerous skin lesion
Surgery

40-49:

Nausea (feeling of having an urge to vomit)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthralgia (joint pain)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Epicondylitis (tennis elbow)
Hypercoagulation (increased tendency for clotting of the blood)
Joint injury
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)
Abdominal abscess (collection of pus in abdomen)

50-59:

Pharyngitis (inflammation of the pharynx, causing a sore throat)
Pneumonia
Pulmonary hypertension (increase in blood pressure in the lung artery)
Pulmonary valve incompetence
Renal failure acute (rapid kidney dysfunction)
Restless legs syndrome (a powerful urge to move your legs)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
Tricuspid valve incompetence (inefficient heart valve)
Type 2 diabetes mellitus

60+:

Hypotension (abnormally low blood pressure)
Vomiting
Dry skin
Dyspnoea exertional (breathlessness or shortness of breath)
Fluid retention (an abnormal accumulation of fluid in the blood)
Humerus fracture (injury to the upper arm bone)
Left ventricular failure (left ventricle fails to contract forcefully)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Neck pain
Oedema (fluid collection in tissue)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 29.41%
Immunodeficiency Common Variable: 10 people, 14.71%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 8.82%
High Blood Pressure: 6 people, 8.82%
Depression: 6 people, 8.82%
Stress And Anxiety: 5 people, 7.35%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 7.35%
High Blood Cholesterol: 5 people, 7.35%
Diabetes: 5 people, 7.35%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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