Provigil and Folate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provigil (modafinil) and Folate (folic acid). Common drug interactions include decreased appetite among females and back pain among males.

The phase IV clinical study analyzes what interactions people have when they take Provigil and Folate. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

51 people who take Provigil and Folate together, and have interactions are studied.

What are the common drug interactions of Provigil and Folate, by gender? *:

female:

Decreased appetite
Depression
Dry eye (lack of adequate tears)
Dry mouth
Dysgraphia (impaired ability to learn to write)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Femoroacetabular impingement (a condition affecting the hip joint in young and middle-aged adults)
Fibromyalgia (a long-term condition which causes pain all over the body)
Gait disturbance
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)

male:

Back pain
Depression
Bladder disorder
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Disturbance in attention
Dizziness
Drug ineffective
Gait disturbance

What are the common drug interactions of Provigil and Folate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Decreased appetite
Malaise (a feeling of general discomfort or uneasiness)
Muscle twitching

30-39:

Heart rate irregular
Hemiparesis (weakness on one side of the body)
Hypoaesthesia (reduced sense of touch or sensation)
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypokalaemia (low potassium)
Migraine (headache)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)
Pain
Pancreatic disorder

40-49:

Back pain
Diarrhoea
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dyspnoea (difficult or laboured respiration)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pneumonia
Alopecia (absence of hair from areas of the body)
Anxiety
Arthralgia (joint pain)
Bladder disorder

50-59:

Affect lability (emotional incontinence)
Aphasia (damage to the parts of the brain that control language)
Constipation
Hypoacusis (loss of hearing)
Irritability
Nausea (feeling of having an urge to vomit)
Nervousness
Pain
Poor quality sleep
Prurigo (chronic skin disease causing severe itching)

60+:

Escherichia urinary tract infection (urinary tract infection by escherichia coli)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Dyspnoea (difficult or laboured respiration)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Headache (pain in head)
Infusion related reaction
Knee arthroplasty
Lung carcinoma cell type unspecified recurrent (lung cancer reoccurrence)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 29.41%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 9.80%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 5 people, 9.80%
Neuropathy Peripheral (surface nerve damage): 4 people, 7.84%
Pain: 3 people, 5.88%
Drowsiness: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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