Provigil and Herceptin drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Provigil (modafinil) and Herceptin (trastuzumab). Common drug interactions include pain among females.
The phase IV clinical study analyzes what interactions people have when they take Provigil and Herceptin. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.
What is Provigil?
Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.
What is Herceptin?
Herceptin has active ingredients of trastuzumab. It is often used in breast cancer. eHealthMe is studying from 42,205 Herceptin users. Check the latest studies of Herceptin.
16 people who take Provigil and Herceptin together, and have interactions are studied.

What are the common drug interactions of Provigil and Herceptin, by gender? *:
female:
- Pain
- Anxiety
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
- Constipation
- Deformity (disfigurement)
- Dysuria (painful or difficult urination)
- Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
- Granuloma (a small area of inflammation due to tissue injury)
- Haemangioma of liver (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in liver)
male:
n/a
What are the common drug interactions of Provigil and Herceptin, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
- Ejection fraction decreased (systolic heart failure)
40-49:
- Atrioventricular block (heart block)
- Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
- Bone loss
- Bradycardia (abnormally slow heart action)
- Breast abscess
- Breath odour
- Breath sounds
- Bronchial wall thickening
- Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
50-59:
- Bone disorder
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Biliary colic
- Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
- Bone swelling
- Bruxism (habitual grinding of the teeth, typically during sleep)
- Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
- Burning sensation
- Cardiomyopathy (weakening of the heart muscle)
- Chest pain
60+:
n/a
What are the existing conditions these people have? *
- Osteoporosis (bones weak and more likely to break): 8 people, 50.00%
- Metastases To Bone (cancer spreads to bone): 8 people, 50.00%
- Breast Cancer Metastatic: 6 people, 37.50%
- Pain: 2 people, 12.50%
- Blood Pressure Abnormal: 2 people, 12.50%
- Thyroid Diseases: 1 person, 6.25%
- Depression: 1 person, 6.25%
- Back Pain: 1 person, 6.25%
- Bipolar Disorder (mood disorder): 1 person, 6.25%
- Breast Cancer Female: 1 person, 6.25%
* Approximation only. Some reports may have incomplete information.
Do you take Provigil and Herceptin?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Provigil and Herceptin:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Provigil:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Herceptin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Provigil and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Herceptin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
- Saleh M, Bourcier T, Noel G, Speeg-Schatz C, Gaucher D, "Bilateral macular ischemia and severe visual loss following trastuzumab therapy", Acta Oncologica, 2011 Apr .
- Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
- Saleh M, Bourcier T, Noel G, Speeg-Schatz C, Gaucher D, "Bilateral macular ischemia and severe visual loss following trastuzumab therapy", Acta Oncologica, 2011 Apr .
How the study uses the data?
The study uses data from the FDA. It is based on modafinil and trastuzumab (the active ingredients of Provigil and Herceptin, respectively), and Provigil and Herceptin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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