Provigil and Methadose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provigil (modafinil) and Methadose (methadone hydrochloride). Common drug interactions include fibromyalgia among females and drug withdrawal syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Provigil and Methadose. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

What is Methadose?

Methadose has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 5,101 Methadose users. Check the latest studies of Methadose.

On Jul, 15, 2026

35 people who take Provigil and Methadose together, and have interactions are studied.

Provigil and Methadose drug interactions.

What are the common drug interactions of Provigil and Methadose, by gender? *:

female:

Fibromyalgia (a long-term condition which causes pain all over the body)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Type 2 diabetes mellitus
Arthropathy
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic coma
Drug intolerance (drug sensitivity)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Intervertebral disc degeneration (spinal disc degeneration)
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)

male:

Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Cardiac disorder
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Drug dependence
Hyperhidrosis (abnormally increased sweating)
Mood altered (changes in mood)
Mood swings (an extreme or rapid change in mood)
Personality change
Pneumonia

What are the common drug interactions of Provigil and Methadose, by age (0-1 to 60+)? *:

0-1:

Colour blindness acquired (development of colour vision disability due to damage to eye)
Depression
Diarrhoea
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Fibromyalgia (a long-term condition which causes pain all over the body)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Adverse drug reaction
Aggression
Agitation (state of anxiety or nervous excitement)
Anger
Anxiety
Arrhythmia (irregular heartbeat)
Blood pressure increased
Cardiac arrest

50-59:

Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysphonia (speech disorder attributable to a disorder of phonation)
Tonic clonic movements (generalized seizure that affects the entire brain)

60+:

Type 2 diabetes mellitus
Diabetic coma
Renal failure chronic (long lasting kidney dysfunction)
Upper respiratory tract infection
Pancreatitis (inflammation of pancreas)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Drug hypersensitivity
Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)

What are the existing conditions these people have? *

Constipation: 23 people, 65.71%
Fibromyalgia (a long-term condition which causes pain all over the body): 23 people, 65.71%
Thyroid Diseases: 21 people, 60.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 20 people, 57.14%
Depression: 20 people, 57.14%
High Blood Cholesterol: 20 people, 57.14%
Muscle Aches (muscle pain): 20 people, 57.14%
Restless Leg Syndrome (a powerful urge to move your legs): 20 people, 57.14%
Sleep Apnea Syndrome: 19 people, 54.29%
Nasal Septum Deviation (deviated nasal septum): 19 people, 54.29%

* Approximation only. Some reports may have incomplete information.

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