Provigil and Zopiclone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Provigil (modafinil) and Zopiclone (eszopiclone). Common drug interactions include nausea among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Provigil and Zopiclone. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 54,330 Zopiclone users. Check the latest studies of Zopiclone.

On Jul, 05, 2026

20 people who take Provigil and Zopiclone together, and have interactions are studied.

Provigil and Zopiclone drug interactions.

What are the common drug interactions of Provigil and Zopiclone, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Agitation (state of anxiety or nervous excitement)
Blood potassium decreased
Blood pressure increased
Campylobacter gastroenteritis (infection of gastrointestinal system)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Decreased appetite
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)

male:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chest pain
Renal impairment (severely reduced kidney function)
Upper respiratory tract infection
Vision blurred
Chronic kidney disease
Depressed mood
Hypoaesthesia (reduced sense of touch or sensation)
Memory impairment
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)

What are the common drug interactions of Provigil and Zopiclone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Burning sensation
Drug administration error
Erythema (redness of the skin)

10-19:

n/a

20-29:

n/a

30-39:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Discomfort
Rash

40-49:

Abdominal pain
Agitation (state of anxiety or nervous excitement)
Blood potassium decreased
Blood pressure increased
Campylobacter gastroenteritis (infection of gastrointestinal system)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Confusional state
Decreased appetite
Dizziness
Dysuria (painful or difficult urination)

50-59:

Depression
Dyspnoea (difficult or laboured respiration)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Generalised erythema (redness of the skin all over the body)
Glomerular filtration rate decreased
Hypoaesthesia (reduced sense of touch or sensation)
Lip swelling
Memory impairment
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

60+:

Chronic kidney disease
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephropathy (damage to or disease of a kidney)
Nephropathy toxic (damage to kidney due to toxins)
Renal impairment (severely reduced kidney function)
Spinal column stenosis (narrowing of spinal column)

What are the existing conditions these people have? *

Sleep Disorder: 4 people, 20.00%
Pain: 4 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 20.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 15.00%
Thyroid Diseases: 2 people, 10.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 10.00%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 10.00%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 10.00%
Nuclear Magnetic Resonance Imaging Brain: 2 people, 10.00%
Nausea (feeling of having an urge to vomit): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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