Prozac and Epclusa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prozac (fluoxetine hydrochloride) and Epclusa (sofosbuvir; velpatasvir). Common drug interactions include headache among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Prozac and Epclusa. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

On Jul, 19, 2026

28 people who take Prozac and Epclusa together, and have interactions are studied.

What are the common drug interactions of Prozac and Epclusa, by gender? *:

female:

Headache (pain in head)
Fatigue (feeling of tiredness)
Weight decreased
Constipation
Drug abuse
Maternal exposure during pregnancy (use of substance during pregnancy)
Nausea (feeling of having an urge to vomit)
Rash
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal discomfort

male:

Fatigue (feeling of tiredness)
Memory impairment
Retroperitoneal haematoma (blood clot between the peritoneum and the posterior abdominal wall)
Sluggishness (lacking alertness)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Abdominal pain
Asthenia (weakness)
Dizziness
Drug ineffective

What are the common drug interactions of Prozac and Epclusa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Fatigue (feeling of tiredness)
Rash

30-39:

Fatigue (feeling of tiredness)
Headache (pain in head)
Maternal exposure during pregnancy (use of substance during pregnancy)

40-49:

Abdominal pain
Alopecia (absence of hair from areas of the body)
Constipation
Dizziness
Fatigue (feeling of tiredness)
Headache (pain in head)
Intrapartum haemorrhage (heavy bleeding during pregnancy)
Pruritus (severe itching of the skin)
Rash
Retroperitoneal haematoma (blood clot between the peritoneum and the posterior abdominal wall)

50-59:

Migraine (headache)

60+:

Asthenia (weakness)
Constipation
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hot flush (sudden feelings of heat)
Hypertension (high blood pressure)
Lethargy (tiredness)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting

What are the existing conditions these people have? *

Hepatitis C: 7 people, 25.00%
Infection: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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