Prozac and Flumazenil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prozac (fluoxetine hydrochloride) and Flumazenil (flumazenil). Common drug interactions include pain among females and extrapyramidal disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Prozac and Flumazenil. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

What is Flumazenil?

Flumazenil has active ingredients of flumazenil. eHealthMe is studying from 982 Flumazenil users. Check the latest studies of Flumazenil.



On Jul, 09, 2026

16 people who take Prozac and Flumazenil together, and have interactions are studied.

Prozac and Flumazenil drug interactions.

What are the common drug interactions of Prozac and Flumazenil, by gender? *:

female:

  1. Pain
  2. Disturbance in attention
  3. Drug ineffective
  4. Knee arthroplasty
  5. Actinic keratosis (skin disease due to sun exposure)
  6. Appendicitis (inflammation of the appendix)
  7. Bone disorder
  8. Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
  9. Dental caries
  10. Duodenal stenosis (block of the first part of the small intestine)

male:

  1. Extrapyramidal disorder (involuntary muscle spasms in the face and neck)

What are the common drug interactions of Prozac and Flumazenil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Extrapyramidal disorder (involuntary muscle spasms in the face and neck)

20-29:

n/a

30-39:

  1. Dizziness
  2. Fatigue (feeling of tiredness)
  3. Vision blurred

40-49:

  1. Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
  2. Impaired healing
  3. Infection
  4. Injury
  5. Loose tooth
  6. Osteonecrosis of jaw (death of bone of jaw)
  7. Pain
  8. Spinal osteoarthritis (joint cartilage loss in spine)
  9. Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
  10. Swelling

50-59:

  1. Pain
  2. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  3. Drug ineffective
  4. Knee arthroplasty
  5. Vomiting
  6. Arthropathy
  7. Body temperature increased
  8. Chills (felling of cold)
  9. Clonus (series of involuntary, rhythmic, muscular contractions and relaxations)
  10. Mydriasis (a dilation of the pupil)

60+:

n/a

What are the existing conditions these people have? *

  1. Procedural Pain: 7 people, 43.75%
  2. Pain: 7 people, 43.75%
  3. Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 6 people, 37.50%
  4. Nausea (feeling of having an urge to vomit): 6 people, 37.50%
  5. Stress And Anxiety: 5 people, 31.25%
  6. Quit Smoking: 4 people, 25.00%
  7. Nervous System Disorder (a general class of medical conditions affecting the nervous system): 4 people, 25.00%
  8. Neurological Symptom (symptoms of nervous system disease): 1 person, 6.25%
  9. Neuralgia (pain in one or more nerves): 1 person, 6.25%
  10. Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Prozac and Flumazenil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prozac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Flumazenil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prozac and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Flumazenil and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride and flumazenil (the active ingredients of Prozac and Flumazenil, respectively), and Prozac and Flumazenil (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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