Prozac and Horizant drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prozac (fluoxetine hydrochloride) and Horizant (gabapentin enacarbil). Common drug interactions include fall among females and blood cholesterol increased among males.

The phase IV clinical study analyzes what interactions people have when they take Prozac and Horizant. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

What is Horizant?

Horizant has active ingredients of gabapentin enacarbil. It is often used in restless leg syndrome. eHealthMe is studying from 2,051 Horizant users. Check the latest studies of Horizant.

On Aug, 11, 2026

37 people who take Prozac and Horizant together, and have interactions are studied.

What are the common drug interactions of Prozac and Horizant, by gender? *:

female:

Fall
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Skin burning sensation
Suicide attempt
Therapeutic response unexpected
White blood cell count decreased
Acne (skin problems that cause pimples)
Asthenia (weakness)

male:

Blood cholesterol increased
Nightmare (unpleasant dream)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Therapeutic response unexpected

What are the common drug interactions of Prozac and Horizant, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood cholesterol increased
Nausea (feeling of having an urge to vomit)
Swelling

30-39:

Nightmare (unpleasant dream)
Therapeutic response unexpected
Abdominal pain
Bladder disorder
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Death
Fatigue (feeling of tiredness)
Headache (pain in head)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

40-49:

Dehydration (dryness resulting from the removal of water)
Gastric ulcer (stomach ulcer)
Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Vomiting

50-59:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cough
Depressed level of consciousness
Drug abuse
Loss of consciousness
Mania (a state of abnormally elevated or irritable mood)
Lung neoplasm malignant (cancer tumour of lung)
Asthenia (weakness)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Contusion (a type of hematoma of tissue in which capillaries)

60+:

Fall
Pyrexia (fever)
Confusional state
Cough
Decreased immune responsiveness
Diplopia (double vision)
Dry skin
Dysstasia (difficulty in standing)
Fatigue (feeling of tiredness)
Foot fracture

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 20 people, 54.05%
Sleep Disorder: 5 people, 13.51%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 13.51%
Drowsiness: 4 people, 10.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 10.81%
Neuropathy Peripheral (surface nerve damage): 2 people, 5.41%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.41%
Constipation: 2 people, 5.41%
Bipolar Disorder (mood disorder): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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