Prozac and Lotronex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prozac (fluoxetine hydrochloride) and Lotronex (alosetron hydrochloride). Common drug interactions include vomiting among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Prozac and Lotronex. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

What is Lotronex?

Lotronex has active ingredients of alosetron hydrochloride. It is often used in irritable bowel syndrome. eHealthMe is studying from 6,841 Lotronex users. Check the latest studies of Lotronex.

On Jul, 09, 2026

71 people who take Prozac and Lotronex together, and have interactions are studied.

What are the common drug interactions of Prozac and Lotronex, by gender? *:

female:

Vomiting
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Asthenia (weakness)
Gastritis (inflammation of stomach)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Rectal haemorrhage (bleeding from anus)
Drug ineffective
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Faecaloma (hard mass of fecal matter)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Arthralgia (joint pain)
Abnormal dreams
Irritability
Neuropathy (damage to nerves)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Personality disorder
Pharyngolaryngeal pain
Rectal haemorrhage (bleeding from anus)
Speech disorder
Suicidal ideation

What are the common drug interactions of Prozac and Lotronex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Mydriasis (a dilation of the pupil)
Sedation
Somnolence (a state of near-sleep, a strong desire for sleep)

20-29:

Abdominal pain
Constipation
Abdominal distension
Adverse event
Antigliadin antibody positive
Colitis (inflammation of colon)
Diarrhoea
Faecaloma (hard mass of fecal matter)
Haemoglobin decreased
Headache (pain in head)

30-39:

Drug ineffective
Dizziness
Rectal haemorrhage (bleeding from anus)
Abnormal dreams
Arthralgia (joint pain)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Confusional state
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disturbance in attention

40-49:

Abdominal pain
Constipation
Gastritis (inflammation of stomach)
Nausea (feeling of having an urge to vomit)
Abdominal distension
Asthenia (weakness)
Blood in stool
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
C-reactive protein increased

50-59:

Flatulence (flatus expelled through the anus)
Gastritis (inflammation of stomach)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrointestinal upset
Haematochezia (passage of stools containing blood)
Incontinence (lack of moderation or self-control)
Infection
Inflammation
Injury
Insomnia (sleeplessness)

60+:

Abdominal pain
Constipation
Anaemia (lack of blood)
Asthenia (weakness)
Back pain
Drug ineffective
Haematocrit decreased
Headache (pain in head)
Ileus paralytic (obstruction of the intestine due to paralysis of the intestinal muscles)
Intestinal perforation (complete penetration of the wall of the intestine)

What are the existing conditions these people have? *

Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 4 people, 5.63%
Pain: 4 people, 5.63%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 4 people, 5.63%
Dyspnea (difficult or laboured breathing): 4 people, 5.63%
Dizziness: 4 people, 5.63%

* Approximation only. Some reports may have incomplete information.

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