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Prozac and Tri-sprintec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prozac (fluoxetine hydrochloride) and Tri-sprintec (ethinyl estradiol; norgestimate). Common drug interactions include cholecystitis chronic among females.

The phase IV clinical study analyzes what interactions people have when they take Prozac and Tri-sprintec. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

What is Tri-sprintec?

Tri-sprintec has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 1,428 Tri-sprintec users. Check the latest studies of Tri-sprintec.

On Jul, 10, 2026

26 people who take Prozac and Tri-sprintec together, and have interactions are studied.

Prozac and Tri-sprintec drug interactions.

What are the common drug interactions of Prozac and Tri-Sprintec, by gender? *:

female:

  1. Cholecystitis chronic (long lasting infection of gallbladder)
  2. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  3. Groin pain
  4. Nausea (feeling of having an urge to vomit)
  5. Sinus disorder (disease of sinus)
  6. Tooth disorder (tooth disease)
  7. Urticaria (rash of round, red welts on the skin that itch intensely)
  8. Vomiting
  9. Abnormal dreams
  10. Abdominal pain

male:

n/a

What are the common drug interactions of Prozac and Tri-Sprintec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Biliary colic
  2. Cholecystitis chronic (long lasting infection of gallbladder)
  3. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  4. Injection site reaction

20-29:

  1. Abnormal dreams
  2. Headache (pain in head)
  3. Hypoaesthesia (reduced sense of touch or sensation)
  4. Injection site bruising
  5. Injection site mass
  6. Injection site pain
  7. Injection site pruritus (severe itching at injection site)
  8. Injection site urticaria (rash of round, red welts on the skin at injection site)
  9. Nausea (feeling of having an urge to vomit)
  10. Pregnancy on oral contraceptive

30-39:

n/a

40-49:

  1. Urethral cyst

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 57.69%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 26.92%
  3. Stress And Anxiety: 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

Do you take Prozac and Tri-sprintec?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Prozac and Tri-sprintec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prozac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Tri-sprintec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prozac and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Tri-sprintec and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride and ethinyl estradiol; norgestimate (the active ingredients of Prozac and Tri-sprintec, respectively), and Prozac and Tri-sprintec (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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