Prozac and Zoladex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Prozac (fluoxetine hydrochloride) and Zoladex (goserelin acetate). Common drug interactions include confusional state among females and metastases to bone among males.

The phase IV clinical study analyzes what interactions people have when they take Prozac and Zoladex. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

What is Zoladex?

Zoladex has active ingredients of goserelin acetate. It is often used in prostate cancer. eHealthMe is studying from 13,870 Zoladex users. Check the latest studies of Zoladex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

37 people who take Prozac and Zoladex together, and have interactions are studied.

What are the common drug interactions of Prozac and Zoladex, by gender? *:

female:

Confusional state
Lethargy (tiredness)
Pain
Anaemia (lack of blood)
Arthropathy
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Mouth ulceration (mouth ulcers)
Nausea (feeling of having an urge to vomit)
Swelling

male:

Metastases to bone (cancer spreads to bone)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Abdominal pain
Abscess jaw (tooth abscess or root abscess)
Alcohol abuse
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arteriosclerosis (thickening and hardening of arteries)
Back pain
Bipolar disorder (mood disorder)
Bone swelling

What are the common drug interactions of Prozac and Zoladex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal distension
Abdominal pain
Arthralgia (joint pain)
Headache (pain in head)
Injection site bruising
Suicidal ideation

40-49:

Fatigue (feeling of tiredness)
Pain
Pyrexia (fever)
Abdominal pain
Hypotension (abnormally low blood pressure)
Metastases to bone (cancer spreads to bone)
Metastases to spine (cancer spreads to spine)
Myalgia (muscle pain)
Oedema peripheral (superficial swelling)
Pain in jaw

50-59:

Tooth impacted (a tooth that fails to fully pass through the gums)
Venous stenosis (abnormal narrowing of veins)
Vomiting
Abdominal distension
Bone neoplasm malignant (cancer of bone)
Localised oedema (fluid retention in a particular part of the body)
Malignant neoplasm progression (cancer tumour came back)
Tooth extraction
Wisdom teeth removal
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)

60+:

Dysphonia (speech disorder attributable to a disorder of phonation)
Metastases to bone (cancer spreads to bone)
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Pemphigoid (tense blisters on the skin)
Pruritus (severe itching of the skin)
Rosacea (a skin condition that causes facial redness)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Urticaria (rash of round, red welts on the skin that itch intensely)
Neoplasm prostate (tumour of prostate)
Vocal cord cyst

What are the existing conditions these people have? *

Breast Cancer: 13 people, 35.14%
Metastases To Bone (cancer spreads to bone): 8 people, 21.62%
Breast Cancer Metastatic: 8 people, 21.62%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 5.41%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.41%
High Blood Pressure: 2 people, 5.41%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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