Psyllium and Janumet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Psyllium (blond psyllium) and Janumet (metformin hydrochloride; sitagliptin phosphate). Common drug interactions include diabetes mellitus inadequate control among females and abdominal distension among males.

The phase IV clinical study analyzes what interactions people have when they take Psyllium and Janumet. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Psyllium?

Psyllium has active ingredients of blond psyllium. It is often used in constipation. eHealthMe is studying from 4,262 Psyllium users. Check the latest studies of Psyllium.

What is Janumet?

Janumet has active ingredients of metformin hydrochloride; sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 25,023 Janumet users. Check the latest studies of Janumet.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

22 people who take Psyllium and Janumet together, and have interactions are studied.

What are the common drug interactions of Psyllium and Janumet, by gender? *:

female:

Diabetes mellitus inadequate control
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blood pressure inadequately controlled
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Contusion (a type of hematoma of tissue in which capillaries)
Depressed mood
Drug ineffective
Exercise tolerance decreased
Hypertension (high blood pressure)
Mobility decreased (ability to move is reduced)

male:

Abdominal distension
Cardiac failure congestive
Suicidal ideation
Weight decreased
Blood glucose increased
Blood triglycerides increased
Cardiac failure
Cataract (clouding of the lens inside the eye)
Chronic kidney disease
Diarrhoea

What are the common drug interactions of Psyllium and Janumet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety disorder
Arthralgia (joint pain)
Back pain
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Blood cholesterol increased
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Depression
Diabetes mellitus inadequate control
Essential hypertension (primary hypertension)

50-59:

Abdominal distension
Cardiac failure congestive
Dysphemia (stammering or stuttering)
Fluid retention (an abnormal accumulation of fluid in the blood)
Liver disorder (liver diseases)
Peripheral swelling
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Somnolence (a state of near-sleep, a strong desire for sleep)
Stress
Suicidal ideation

60+:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blood pressure inadequately controlled
Oedema peripheral (superficial swelling)
Peripheral swelling
Abdominal discomfort
Decreased appetite
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperglycaemic hyperosmolar nonketotic syndrome (too much sugar (glucose) in your blood)
Pyrexia (fever)
Weight decreased

What are the existing conditions these people have? *

Pain: 11 people, 50.00%
Cough: 9 people, 40.91%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 9 people, 40.91%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 8 people, 36.36%
Restless Leg Syndrome (a powerful urge to move your legs): 8 people, 36.36%
Psoriasis (immune-mediated disease that affects the skin): 8 people, 36.36%
Osteoporosis (bones weak and more likely to break): 8 people, 36.36%
Oedema (fluid collection in tissue): 8 people, 36.36%
Gout (uric acid crystals building up in the body): 8 people, 36.36%
High Blood Pressure: 8 people, 36.36%

* Approximation only. Some reports may have incomplete information.

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