Psyllium and Opsumit drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Psyllium (blond psyllium) and Opsumit (macitentan). Common drug interactions include weight fluctuation among females and oxygen saturation decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Psyllium and Opsumit. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Psyllium?

Psyllium has active ingredients of blond psyllium. It is often used in constipation. eHealthMe is studying from 4,262 Psyllium users. Check the latest studies of Psyllium.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

On Jul, 12, 2026

14 people who take Psyllium and Opsumit together, and have interactions are studied.

What are the common drug interactions of Psyllium and Opsumit, by gender? *:

female:

Weight fluctuation
Cardiac failure congestive
Death
Dyspnoea (difficult or laboured respiration)
Muscle tightness
Oedema peripheral (superficial swelling)
Poor quality sleep
Pulmonary hypertension (increase in blood pressure in the lung artery)
Body height decreased
Overdose

male:

Oxygen saturation decreased
Diarrhoea
Continuous positive airway pressure
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Fall
Fluid retention (an abnormal accumulation of fluid in the blood)
Gait disturbance
Gangrene (body tissue dies)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Psyllium and Opsumit, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Cardiac failure congestive
Oxygen saturation decreased
Cardiac failure acute
Continuous positive airway pressure
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Fall
Fluid retention (an abnormal accumulation of fluid in the blood)

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 11 people, 78.57%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 7 people, 50.00%
Systemic Sclerosis (Scleroderma) (an autoimmune or connective tissue disease. it is characterized by thickening of the skin): 4 people, 28.57%
Interstitial Lung Disease: 4 people, 28.57%
Diarrhea: 4 people, 28.57%
High Blood Pressure: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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