Pulmicort flexhaler and Restasis drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Pulmicort flexhaler (budesonide) and Restasis (cyclosporine). Common drug interactions include hypoaesthesia among females and diarrhoea among males.
The phase IV clinical study analyzes what interactions people have when they take Pulmicort flexhaler and Restasis. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.
What is Pulmicort flexhaler?
Pulmicort flexhaler has active ingredients of budesonide. It is often used in asthma. eHealthMe is studying from 5,527 Pulmicort flexhaler users. Check the latest studies of Pulmicort flexhaler.
What is Restasis?
Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.
29 people who take Pulmicort flexhaler and Restasis together, and have interactions are studied.

What are the common drug interactions of Pulmicort Flexhaler and Restasis, by gender? *:
female:
- Hypoaesthesia (reduced sense of touch or sensation)
- Hypoaesthesia oral (reduced sense of touch or sensation in mouth)
- Hypotonia (low muscle tone)
- Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
- Influenza like illness
- Injury
- Insomnia (sleeplessness)
- Lip erosion (peeling off of lip)
- Liver disorder (liver diseases)
- Lymphocytic infiltration (lymphocyte deposition)
male:
- Diarrhoea
- Abdominal pain
- Emotional distress
- Fatigue (feeling of tiredness)
- Foot fracture
- General physical health deterioration (weak health status)
- Hypertension (high blood pressure)
- Hypotension (abnormally low blood pressure)
- Ill-defined disorder
- Infusion site reaction
What are the common drug interactions of Pulmicort Flexhaler and Restasis, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Alanine aminotransferase increased
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Aspartate aminotransferase increased
- Blood alkaline phosphatase increased
- Blood lactate dehydrogenase increased
- Blood pressure decreased
- Brain injury
- C-reactive protein increased
- Cerebral haemorrhage (bleeding within the brain)
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
30-39:
n/a
40-49:
- Abnormal dreams
- Asthenia (weakness)
- Balance disorder
- Depression
- Dysstasia (difficulty in standing)
- Eye disorder
- Fatigue (feeling of tiredness)
- Fear of falling
- Suicidal ideation
50-59:
- Splenomegaly (enlargement of spleen)
- Tympanic membrane perforation (a break in continuity of ear drum)
- Upper limb fracture
- Accident
- Anger
- Balance disorder
- Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels)
- Cough
- Decreased activity
- Depression
60+:
- Glaucoma (increased fluid pressure in the eye with vision loss)
- Visual impairment
- Osteoporosis (bones weak and more likely to break)
- Pain
- Vomiting
- Cough
- Dyspnoea (difficult or laboured respiration)
- Wheezing (a high-pitched whistling sound made while you breath)
- Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
- Anhedonia (inability to experience pleasure from activities usually found enjoyable)
What are the existing conditions these people have? *
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 17.24%
- Multiple Allergies (allergy to multiple agents): 5 people, 17.24%
- Neuropathy Peripheral (surface nerve damage): 5 people, 17.24%
- Blood Pressure Abnormal: 4 people, 13.79%
- Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 13.79%
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 13.79%
- Blood Glucose Abnormal: 4 people, 13.79%
- Arthritis (form of joint disorder that involves inflammation of one or more joints): 4 people, 13.79%
- Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 3 people, 10.34%
- Cardiac Disorder: 3 people, 10.34%
* Approximation only. Some reports may have incomplete information.
Do you take Pulmicort flexhaler and Restasis?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Pulmicort flexhaler (5,527 reports)
- Restasis (35,199 reports)
Browse all drug interactions of Pulmicort flexhaler and Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Pulmicort flexhaler:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Restasis:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Pulmicort flexhaler and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Restasis and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
- O’Brien FE, O’Connor RM, Clarke G, Donovan MD, Dinan TG, Griffin BT, Cryan JF, "The P-glycoprotein inhibitor cyclosporin A differentially influences behavioural and neurochemical responses to the antidepressant escitalopram", Behavioural brain research, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on budesonide and cyclosporine (the active ingredients of Pulmicort flexhaler and Restasis, respectively), and Pulmicort flexhaler and Restasis (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
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