Pylera and Truvada drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pylera (bismuth subcitrate potassium; metronidazole; tetracycline) and Truvada (emtricitabine; tenofovir disoproxil fumarate). Common drug interactions include anhedonia among females and pain among males.

The phase IV clinical study analyzes what interactions people have when they take Pylera and Truvada. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Pylera?

Pylera has active ingredients of bismuth subcitrate potassium; metronidazole; tetracycline. eHealthMe is studying from 1,036 Pylera users. Check the latest studies of Pylera.

What is Truvada?

Truvada has active ingredients of emtricitabine; tenofovir disoproxil fumarate. It is often used in hiv infection. eHealthMe is studying from 76,246 Truvada users. Check the latest studies of Truvada.

On Aug, 01, 2026

11 people who take Pylera and Truvada together, and have interactions are studied.

What are the common drug interactions of Pylera and Truvada, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Bone density decreased
Osteoporosis (bones weak and more likely to break)
Tooth loss
Depression
Fracture
Osteopenia (a condition where bone mineral density is lower than normal)

male:

Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Muscular weakness (muscle weakness)
Osteomalacia (softening of the bones due to a lack of vitamin d)
Rib fracture
Bone density decreased
Acute stress disorder
Cd4 lymphocytes decreased
Constipation
Depression

What are the common drug interactions of Pylera and Truvada, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Abdominal discomfort
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone density decreased
Cardiac amyloidosis (protein deposition in heart)
Cardiac disorder
Chronic kidney disease
Drug resistance (reduction in effectiveness of a drug)
Emotional distress
Fatigue (feeling of tiredness)

30-39:

n/a

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Bone density decreased
Osteoporosis (bones weak and more likely to break)
Tooth loss
Depression
Fracture
Osteopenia (a condition where bone mineral density is lower than normal)

50-59:

Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Rib fracture
Acute stress disorder
Cd4 lymphocytes decreased
Constipation
Depression
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Drug eruption (adverse drug reaction of the skin)
Dry throat

60+:

n/a

What are the existing conditions these people have? *

Hepatitis C: 1 person, 9.09%
Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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