Pyrazinamide and Cyclophosphamide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pyrazinamide (pyrazinamide) and Cyclophosphamide (cyclophosphamide). Common drug interactions include red blood cell sedimentation rate increased among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Pyrazinamide and Cyclophosphamide. It is created by eHealthMe based on reports of 83 people who take the same drugs from the FDA, and is updated regularly.

What is Pyrazinamide?

Pyrazinamide has active ingredients of pyrazinamide. It is often used in tuberculosis. eHealthMe is studying from 10,062 Pyrazinamide users. Check the latest studies of Pyrazinamide.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

On Aug, 06, 2026

83 people who take Pyrazinamide and Cyclophosphamide together, and have interactions are studied.

Pyrazinamide and Cyclophosphamide drug interactions.

What are the common drug interactions of Pyrazinamide and Cyclophosphamide, by gender? *:

female:

Red blood cell sedimentation rate increased
Respiratory failure (inadequate gas exchange by the respiratory system)
T-lymphocyte count decreased
Rash
Alveolitis (inflammation in the socket of a tooth)
Drug ineffective
Hydrocephalus (water on the brain)
Interstitial lung disease
Meningitis tuberculous (a bacterial infection of the membranes covering the brain and spinal cord (meninges))
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

male:

Drug ineffective
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Disseminated tuberculosis
Alanine aminotransferase increased
Mycobacterial infection
Pyrexia (fever)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Febrile neutropenia (fever with reduced white blood cells)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Paradoxical drug reaction

What are the common drug interactions of Pyrazinamide and Cyclophosphamide, by age (0-1 to 60+)? *:

0-1:

Deafness
Transaminases increased
Engraftment syndrome (inflammatory condition during neutrophil recovery after hematopoietic stem cell transplantation)
Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)

2-9:

Pulmonary tuberculosis (lungs tuberculosis)
Atelectasis (partial or complete collapse of the lung)
Drug ineffective
Hepatic enzyme increased
Lymph node tuberculosis
Lymphadenopathy (disease or enlargement of lymph nodes)
Respiratory failure (inadequate gas exchange by the respiratory system)
Pyrexia (fever)

10-19:

Anaemia (lack of blood)
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Leukopenia (less number of white blood cells in blood)
Alanine aminotransferase increased
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)

20-29:

Disseminated tuberculosis
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Cough
Decreased appetite
Disease progression
Glomerulonephritis proliferative (a disorder of the glomeruli (glomerulonephritis), or small blood vessels in the kidneys)
Hepatotoxicity (chemical-driven liver damage)
Hydrocephalus (water on the brain)
Hypokalaemia (low potassium)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

30-39:

Pyrexia (fever)
Abdominal pain
C-reactive protein increased
Alanine aminotransferase increased
Ascites (accumulation of fluid in the abdominal cavity)
Cd4 lymphocytes decreased
Diarrhoea
Gamma-glutamyltransferase increased
Globulins increased
Lymphadenopathy (disease or enlargement of lymph nodes)

40-49:

Pulmonary tuberculosis (lungs tuberculosis)
Sacroiliitis (an inflammation of the sacroiliac joint)
Tuberculosis test positive
Vomiting
White blood cell count decreased
Drug ineffective
Mycobacterial infection
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Paradoxical drug reaction
Pyrexia (fever)

50-59:

Drug ineffective
General physical health deterioration (weak health status)
Neutropenia (an abnormally low number of neutrophils)
Alopecia (absence of hair from areas of the body)
Alveolitis (inflammation in the socket of a tooth)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Cerebral toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii)
Confusional state
Csf glucose decreased
Csf protein increased

60+:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Retroperitoneal haemorrhage (bleeding between the peritoneum and the posterior abdominal wall)
Paradoxical drug reaction
Pneumonia bacterial (pneumonia associated with bacterial infection)
Pulmonary tuberculosis (lungs tuberculosis)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Tuberculoma of central nervous system (a tumour-like mass that is not a cancer in brain, a complication of tuberculosis)
Tuberculosis gastrointestinal (a bacterial infection of digestive tract by mycobacterium tuberculosis)

What are the existing conditions these people have? *

Pulmonary Tuberculosis (lungs tuberculosis): 16 people, 19.28%
Disseminated Tuberculosis: 13 people, 15.66%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 12 people, 14.46%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 9 people, 10.84%
Mycobacterium Tuberculosis Complex Test Positive: 5 people, 6.02%
Meningitis Tuberculous (a bacterial infection of the membranes covering the brain and spinal cord (meninges)): 5 people, 6.02%
Cryptococcosis (potentially fatal fungal disease): 5 people, 6.02%

* Approximation only. Some reports may have incomplete information.

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