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Pyridium and Differin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pyridium (phenazopyridine hydrochloride) and Differin (adapalene). Common drug interactions include juvenile myoclonic epilepsy among females.

The phase IV clinical study analyzes what interactions people have when they take Pyridium and Differin. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Pyridium?

Pyridium has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,841 Pyridium users. Check the latest studies of Pyridium.

What is Differin?

Differin has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 5,740 Differin users. Check the latest studies of Differin.

On Jul, 18, 2026

13 people who take Pyridium and Differin together, and have interactions are studied.

Pyridium and Differin drug interactions.

What are the common drug interactions of Pyridium and Differin, by gender? *:

female:

  1. Juvenile myoclonic epilepsy (childhood epilepsy occurring early in morning affecting 12 to 18 years)
  2. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  3. Stress fracture (fracture of a bone caused by repeated (rather than sudden) mechanical stress)
  4. Syncope (loss of consciousness with an inability to maintain postural tone)
  5. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  6. Loss of consciousness
  7. Heart rate increased
  8. Hospitalisation
  9. Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
  10. Cardiac arrest

male:

n/a

What are the common drug interactions of Pyridium and Differin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Juvenile myoclonic epilepsy (childhood epilepsy occurring early in morning affecting 12 to 18 years)
  3. Tachycardia (a heart rate that exceeds the range of 100 beats/min)
  4. Loss of consciousness
  5. Heart rate increased
  6. Hospitalisation
  7. Cardiac arrest
  8. Blood pressure increased
  9. Drug hypersensitivity
  10. Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 92.31%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 92.31%

* Approximation only. Some reports may have incomplete information.

Do you take Pyridium and Differin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Pyridium and Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Pyridium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Differin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pyridium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Differin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on phenazopyridine hydrochloride and adapalene (the active ingredients of Pyridium and Differin, respectively), and Pyridium and Differin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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