Pyridium and Heparin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pyridium (phenazopyridine hydrochloride) and Heparin (heparin sodium). Common drug interactions include maculopathy among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Pyridium and Heparin. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Pyridium?

Pyridium has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,841 Pyridium users. Check the latest studies of Pyridium.

What is Heparin?

Heparin has active ingredients of heparin sodium. It is often used in blood clots. eHealthMe is studying from 92,141 Heparin users. Check the latest studies of Heparin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 02, 2026

70 people who take Pyridium and Heparin together, and have interactions are studied.

What are the common drug interactions of Pyridium and Heparin, by gender? *:

female:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Myalgia (muscle pain)
Night sweats (sweating in night)
Renal failure chronic (long lasting kidney dysfunction)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Skin graft infection
Skin irritation
Upper respiratory tract infection
Urinary tract infection pseudomonal
Vomiting

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Pneumonia
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
Pneumonia fungal
Pulmonary alveolar haemorrhage (acute bleeding)
Staphylococcal bacteraemia (a bacterial infection of blood)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Vomiting
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)

What are the common drug interactions of Pyridium and Heparin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Contusion (a type of hematoma of tissue in which capillaries)
Electrocardiogram qt prolonged
Enterococcal bacteraemia (presence of bacteria lactic acid in the blood)
Haemorrhagic diathesis (bleeding tendency)
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
Pneumonia fungal
Pulmonary alveolar haemorrhage (acute bleeding)
Staphylococcal bacteraemia (a bacterial infection of blood)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

20-29:

n/a

30-39:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Juvenile myoclonic epilepsy (childhood epilepsy occurring early in morning affecting 12 to 18 years)
Loss of consciousness
Heart rate increased
Hospitalisation
Platelet count decreased
Pyrexia (fever)
White blood cell count decreased
Cardiac arrest
Blood pressure increased

40-49:

Disease recurrence
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hunger
Renal failure (kidney dysfunction)
Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances)
Vulvovaginal pain
Abdominal abscess (collection of pus in abdomen)
Dyspnoea (difficult or laboured respiration)
Face oedema (swelling of face)
Fistula (an abnormal connection or passageway between two)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Bursitis infective (the bursa can become infected, this is called infected bursitis)
Cellulitis (infection under the skin)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Death
Nephrogenic anaemia (anaemia due to kidney disease)
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Pneumonia
Asthenia (weakness)

60+:

Pneumonia
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Sinusitis (inflammation of sinus)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Asthenia (weakness)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Bladder dysfunction
Blood pressure decreased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 18.57%
Pain: 12 people, 17.14%
High Blood Pressure: 11 people, 15.71%
Depression: 11 people, 15.71%
Cystitis Interstitial (unknown cause characterized by bladder pain): 10 people, 14.29%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 12.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 12.86%
Constipation: 8 people, 11.43%
Immunodeficiency Common Variable: 8 people, 11.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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