Pyridium and Medrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pyridium (phenazopyridine hydrochloride) and Medrol (methylprednisolone). Common drug interactions include abscess limb among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Pyridium and Medrol. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Pyridium?

Pyridium has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,841 Pyridium users. Check the latest studies of Pyridium.

What is Medrol?

Medrol has active ingredients of methylprednisolone. It is often used in rheumatoid arthritis. eHealthMe is studying from 24,443 Medrol users. Check the latest studies of Medrol.

On Jul, 03, 2026

29 people who take Pyridium and Medrol together, and have interactions are studied.

What are the common drug interactions of Pyridium and Medrol, by gender? *:

female:

Abscess limb (limb infection)
Acute respiratory failure
Bacterial test positive
Candida pneumonia (infection of lung by candida)
Cardiac disorder
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Dyspnoea (difficult or laboured respiration)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Eructation (release of gas from the digestive tract)

male:

Chest pain
Chronic kidney disease
Depression
Multiple fractures
Neoplasm malignant (cancer tumour)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Prostate cancer
Vitamin d deficiency
Adverse reaction

What are the common drug interactions of Pyridium and Medrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Activities of daily living impaired
Arthralgia (joint pain)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Comminuted fracture (bone has broken into several pieces)
Cystitis interstitial (unknown cause characterized by bladder pain)
Fall
Femur fracture
Haemoglobin decreased
Mobility decreased (ability to move is reduced)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

30-39:

Chronic kidney disease
Dyspepsia (indigestion)
Gastritis (inflammation of stomach)
Renal failure (kidney dysfunction)

40-49:

Tenderness (pain or discomfort when an affected area is touched)
Tinnitus (a ringing in the ears)
Tooth fracture
Pain
Emotional distress
Injury
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Blood creatinine increased

50-59:

Clavicle fracture
Foot fracture
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Chronic kidney disease
Hand fracture
Renal failure (kidney dysfunction)

60+:

Fall
Pain in extremity
Haemoglobin decreased
Hysterectomy
Post procedural haemorrhage (post procedural bleeding)
Ankle fracture
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bone disorder
Cervical vertebral fracture
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

What are the existing conditions these people have? *

Pain: 11 people, 37.93%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 20.69%
Osteoporosis (bones weak and more likely to break): 5 people, 17.24%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 13.79%
Infection: 4 people, 13.79%
Indigestion: 4 people, 13.79%
Hiv Infection: 3 people, 10.34%
Nausea (feeling of having an urge to vomit): 3 people, 10.34%
High Blood Pressure: 3 people, 10.34%
Depression: 3 people, 10.34%

* Approximation only. Some reports may have incomplete information.

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