Pyridium and Modafinil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pyridium (phenazopyridine hydrochloride) and Modafinil (modafinil). Common drug interactions include diarrhoea among females.

The phase IV clinical study analyzes what interactions people have when they take Pyridium and Modafinil. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Pyridium?

Pyridium has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,841 Pyridium users. Check the latest studies of Pyridium.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

On Jul, 28, 2026

42 people who take Pyridium and Modafinil together, and have interactions are studied.

Pyridium and Modafinil drug interactions.

What are the common drug interactions of Pyridium and Modafinil, by gender? *:

female:

Diarrhoea
Hospitalisation
Osteoporosis (bones weak and more likely to break)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Rib fracture
Splenic haematoma (blood clot in spleen)
Splenic rupture
Weight decreased
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)

male:

n/a

What are the common drug interactions of Pyridium and Modafinil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hospitalisation
Surgery
Abdominal distension
Anaemia (lack of blood)
Depression
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Suicidal ideation

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Drug hypersensitivity
Limb injury
Hospitalisation
Cystitis interstitial (unknown cause characterized by bladder pain)
Hysterectomy
Irritable bowel syndrome
Laryngitis (inflammation of the larynx)

50-59:

Small cell lung cancer metastatic (lung cancer spreads to other body parts)
Vomiting
Actinic keratosis (skin disease due to sun exposure)
Affect lability (emotional incontinence)
Balance disorder
Blood pressure orthostatic
Depression
Dysarthria (speech disorder)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea exertional (breathlessness or shortness of breath)

60+:

Delirium (wild excitement)
Eye injury
Fall
Insomnia (sleeplessness)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 24 people, 57.14%
Drowsiness: 7 people, 16.67%
Fluid Imbalance (imbalance of fluid in body in intake and fluid lost): 5 people, 11.90%
Trigeminal Neuralgia (a painful condition of the nerve responsible for most facial sensation): 3 people, 7.14%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 7.14%
Gait Disturbance: 3 people, 7.14%
Fatigue (feeling of tiredness): 3 people, 7.14%
Depression: 3 people, 7.14%
Affect Lability (emotional incontinence): 3 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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