Pyridium and Prolia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pyridium (phenazopyridine hydrochloride) and Prolia (denosumab). Common drug interactions include maculopathy among females.

The phase IV clinical study analyzes what interactions people have when they take Pyridium and Prolia. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Pyridium?

Pyridium has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,841 Pyridium users. Check the latest studies of Pyridium.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 21, 2026

13 people who take Pyridium and Prolia together, and have interactions are studied.

What are the common drug interactions of Pyridium and Prolia, by gender? *:

female:

Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)
Aortic valve stenosis (narrowing of the aortic valve)
Presbyopia (a condition in which the lens of the eye loses its ability to focus, making it difficult to see objects up close)
Renal disorder (kidney disease)
Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Arthralgia (joint pain)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Balance disorder
Breast cancer metastatic

male:

n/a

What are the common drug interactions of Pyridium and Prolia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest)

50-59:

n/a

60+:

Aortic valve stenosis (narrowing of the aortic valve)
Asthenia (weakness)
Anaemia (lack of blood)
Arthralgia (joint pain)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Balance disorder
Breast cancer metastatic
Cardiac failure congestive
Cor pulmonale (enlargement of the right ventricle of the heart)
Cough

What are the existing conditions these people have? *

Pain: 5 people, 38.46%
High Blood Pressure: 4 people, 30.77%
Muscle Spasms (muscle contraction): 3 people, 23.08%
Menopause (end of monthly cycles in women): 3 people, 23.08%
Cystitis Interstitial (unknown cause characterized by bladder pain): 3 people, 23.08%
Insomnia (sleeplessness): 3 people, 23.08%
Rashes (redness): 3 people, 23.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 23.08%
Nausea (feeling of having an urge to vomit): 3 people, 23.08%
High Blood Cholesterol: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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