Pyridostigmine bromide and Hydrochlorothiazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pyridostigmine bromide (pyridostigmine bromide) and Hydrochlorothiazide (hydrochlorothiazide). Common drug interactions include infusion site extravasation among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Pyridostigmine bromide and Hydrochlorothiazide. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Pyridostigmine bromide?

Pyridostigmine bromide has active ingredients of pyridostigmine bromide. It is often used in myasthenia gravis. eHealthMe is studying from 1,948 Pyridostigmine bromide users. Check the latest studies of Pyridostigmine bromide.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

On Jul, 13, 2026

43 people who take Pyridostigmine bromide and Hydrochlorothiazide together, and have interactions are studied.

Pyridostigmine bromide and Hydrochlorothiazide drug interactions.

What are the common drug interactions of Pyridostigmine Bromide and Hydrochlorothiazide, by gender? *:

female:

Infusion site extravasation (flow of (blood or lymph) from infusion site)
Insomnia (sleeplessness)
Iron deficiency
Lethargy (tiredness)
Leukopenia (less number of white blood cells in blood)
Lumbar spinal stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone)
Malignant melanoma in situ (early stage of cancer in melanocyte)
Mass
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Meningitis aseptic (a condition that causes the membranes covering your brain and spinal cord to become inflamed)

male:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Nasopharyngitis (inflammation of the nasopharynx)
Pain in extremity
Weight increased
Abdominal discomfort
Affect lability (emotional incontinence)
Arthralgia (joint pain)
Blood glucose increased
Blood pressure decreased

What are the common drug interactions of Pyridostigmine Bromide and Hydrochlorothiazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Headache (pain in head)
Infusion related reaction
Road traffic accident
Varicose vein (veins that have become enlarged and tortuous)

40-49:

n/a

50-59:

Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Sluggishness (lacking alertness)
Stress
Arthropathy
Asthenia (weakness)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Drug ineffective
Frostbite (damage is caused to skin and other tissues due to freezing)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)

60+:

Fatigue (feeling of tiredness)
Asthenia (weakness)
Nasopharyngitis (inflammation of the nasopharynx)
Pain
Pain in extremity
Poor quality sleep
Rash
Vitamin d deficiency
Deafness unilateral
Dizziness

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 11.63%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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