Pyridoxine and Hydroxyurea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Pyridoxine (pyridoxine (vitamin b6)) and Hydroxyurea (hydroxyurea). Common drug interactions include fatigue among females and acute myeloid leukaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Pyridoxine and Hydroxyurea. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Pyridoxine?

Pyridoxine has active ingredients of pyridoxine (vitamin b6). eHealthMe is studying from 8,747 Pyridoxine users. Check the latest studies of Pyridoxine.

What is Hydroxyurea?

Hydroxyurea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 17,240 Hydroxyurea users. Check the latest studies of Hydroxyurea.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

15 people who take Pyridoxine and Hydroxyurea together, and have interactions are studied.

Pyridoxine and Hydroxyurea drug interactions.

What are the common drug interactions of Pyridoxine and Hydroxyurea, by gender? *:

female:

Fatigue (feeling of tiredness)
Dacryostenosis acquired (obstruction of the nasolacrimal duct-acquired)
Face oedema (swelling of face)
Myalgia (muscle pain)
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Acute pulmonary oedema (sudden deposit of fluid in the lung))
Acute respiratory distress syndrome
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Dizziness

male:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Epistaxis (bleed from the nose)
Cardiac failure congestive
Chronic kidney disease
Colonic pseudo-obstruction (severe impairment in the ability of the intestines to push food through)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Essential thrombocythaemia (chronic blood cancer)
Haematuria (presence of blood in urine)
Nephrogenic anaemia (anaemia due to kidney disease)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the common drug interactions of Pyridoxine and Hydroxyurea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Dacryostenosis acquired (obstruction of the nasolacrimal duct-acquired)
Face oedema (swelling of face)
Fatigue (feeling of tiredness)
Myalgia (muscle pain)
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Surgery

40-49:

n/a

50-59:

Colonic pseudo-obstruction (severe impairment in the ability of the intestines to push food through)

60+:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Epistaxis (bleed from the nose)
Blood potassium decreased
Cardiac failure congestive
Chronic kidney disease
Encephalopathy (functioning of the brain is affected by some agent or condition)
Essential thrombocythaemia (chronic blood cancer)
Haematuria (presence of blood in urine)
Nephrogenic anaemia (anaemia due to kidney disease)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

What are the existing conditions these people have? *

Pain: 6 people, 40.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 26.67%
Sinusitis (inflammation of sinus): 4 people, 26.67%
High Blood Pressure: 4 people, 26.67%
Multiple Myeloma (cancer of the plasma cells): 4 people, 26.67%
Anaemia (lack of blood): 4 people, 26.67%
Haemorrhage (bleeding): 3 people, 20.00%
Nausea (feeling of having an urge to vomit): 3 people, 20.00%
White Blood Cell Count Abnormal: 3 people, 20.00%
Sinusitis Fungal (fungal infection of sinus): 3 people, 20.00%

* Approximation only. Some reports may have incomplete information.

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