Ranexa and Divalproex sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ranexa (ranolazine) and Divalproex sodium (divalproex sodium). Common drug interactions include urinary tract infection among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Ranexa and Divalproex sodium. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Ranexa?

Ranexa has active ingredients of ranolazine. It is often used in angina. eHealthMe is studying from 11,758 Ranexa users. Check the latest studies of Ranexa.

What is Divalproex sodium?

Divalproex sodium has active ingredients of divalproex sodium. It is often used in epilepsy. eHealthMe is studying from 9,483 Divalproex sodium users. Check the latest studies of Divalproex sodium.



On Jul, 07, 2026

18 people who take Ranexa and Divalproex sodium together, and have interactions are studied.

Ranexa and Divalproex sodium drug interactions.

What are the common drug interactions of Ranexa and Divalproex Sodium, by gender? *:

female:

  1. Urinary tract infection
  2. Asthenia (weakness)
  3. Cardiac failure
  4. Cataract (clouding of the lens inside the eye)
  5. Chills (felling of cold)
  6. Chronic kidney disease
  7. Diarrhoea
  8. Dysstasia (difficulty in standing)
  9. Fall
  10. Fatigue (feeling of tiredness)

male:

  1. Abdominal pain upper
  2. Chronic kidney disease
  3. Somnolence (a state of near-sleep, a strong desire for sleep)
  4. Epistaxis (bleed from the nose)
  5. Urinary incontinence (inability to control the flow of urine and involuntary urination)
  6. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  7. Nephrogenic anaemia (anaemia due to kidney disease)
  8. Renal failure (kidney dysfunction)
  9. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  10. Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)

What are the common drug interactions of Ranexa and Divalproex Sodium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Chronic kidney disease
  2. Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
  3. Nephrogenic anaemia (anaemia due to kidney disease)
  4. Renal failure (kidney dysfunction)
  5. Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
  6. Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)

60+:

  1. Urinary tract infection
  2. Chronic kidney disease
  3. Headache (pain in head)
  4. Limb injury
  5. Malaise (a feeling of general discomfort or uneasiness)
  6. Oxygen saturation decreased
  7. Pelvic fracture
  8. Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
  9. Pyrexia (fever)
  10. Streptococcal infection

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 10 people, 55.56%
  2. Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 3 people, 16.67%
  3. Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 3 people, 16.67%
  4. Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi): 2 people, 11.11%
  5. Indigestion: 2 people, 11.11%
  6. Infusion Site Discomfort: 2 people, 11.11%
  7. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
  8. Neuralgia (pain in one or more nerves): 2 people, 11.11%
  9. Diabetes: 2 people, 11.11%
  10. Depression: 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Ranexa and Divalproex sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ranexa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Divalproex sodium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ranexa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Divalproex sodium and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on ranolazine and divalproex sodium (the active ingredients of Ranexa and Divalproex sodium, respectively), and Ranexa and Divalproex sodium (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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