Ranexa and Ketoconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ranexa (ranolazine) and Ketoconazole (ketoconazole). Common drug interactions include renal impairment among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Ranexa and Ketoconazole. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Ranexa?

Ranexa has active ingredients of ranolazine. It is often used in angina. eHealthMe is studying from 11,758 Ranexa users. Check the latest studies of Ranexa.

What is Ketoconazole?

Ketoconazole has active ingredients of ketoconazole. It is often used in fungal infection. eHealthMe is studying from 16,014 Ketoconazole users. Check the latest studies of Ketoconazole.

On Jul, 17, 2026

77 people who take Ranexa and Ketoconazole together, and have interactions are studied.

Ranexa and Ketoconazole drug interactions.

What are the common drug interactions of Ranexa and Ketoconazole, by gender? *:

female:

Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Urinary tract infection
Menopause (end of monthly cycles in women)
Menstruation irregular
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Back pain

male:

Chronic kidney disease
Anxiety
Cystitis (inflammation of the wall of the bladder)
Dehydration (dryness resulting from the removal of water)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Fall
Hospitalisation
Hot flush (sudden feelings of heat)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the common drug interactions of Ranexa and Ketoconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Menopause (end of monthly cycles in women)
Menstruation irregular
Headache (pain in head)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Vulvovaginal mycotic infection (vulvovaginal fungal infection)

50-59:

Rib fracture
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Bone density decreased
Cardiac disorder
Cataract (clouding of the lens inside the eye)
Chronic kidney disease
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Death
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Blood glucose decreased
Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hot flush (sudden feelings of heat)
Infection
Stent placement
Urinary tract infection
Vomiting

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 18 people, 23.38%
Hyperkalemia (damage to or disease of the kidney): 16 people, 20.78%
High Blood Pressure: 14 people, 18.18%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 18.18%
Cardiac Disorder: 13 people, 16.88%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 14.29%
Pain: 11 people, 14.29%
Stable Angina (a constant chest pain): 11 people, 14.29%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 10 people, 12.99%
High Blood Cholesterol: 10 people, 12.99%

* Approximation only. Some reports may have incomplete information.

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