Ranitidine hydrochloride and Cotrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ranitidine hydrochloride (ranitidine hydrochloride) and Cotrim (sulfamethoxazole; trimethoprim). Common drug interactions include toxic epidermal necrolysis among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Ranitidine hydrochloride and Cotrim. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Ranitidine hydrochloride?

Ranitidine hydrochloride has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 76,413 Ranitidine hydrochloride users. Check the latest studies of Ranitidine hydrochloride.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

On Jul, 11, 2026

25 people who take Ranitidine hydrochloride and Cotrim together, and have interactions are studied.

Ranitidine hydrochloride and Cotrim drug interactions.

What are the common drug interactions of Ranitidine Hydrochloride and Cotrim, by gender? *:

female:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Normochromic normocytic anaemia (forms of anaemia in which the average size and haemoglobin content of the red blood cells are within normal limits)
Pyrexia (fever)
Anaemia (lack of blood)
Communication disorder (speech and language disorder)
Cough
Leukopenia (less number of white blood cells in blood)
Memory impairment
Metastases to central nervous system (cancer spreads to central nervous system)
Mobility decreased (ability to move is reduced)

male:

Vomiting
Dyspnoea (difficult or laboured respiration)
Activated partial thromboplastin time prolonged
Anaemia (lack of blood)
Anaemia neonatal
Anger
Anion gap increased
Apgar score low
Arthralgia (joint pain)
Blood amylase increased

What are the common drug interactions of Ranitidine Hydrochloride and Cotrim, by age (0-1 to 60+)? *:

0-1:

Anaemia neonatal
Apgar score low
Constipation
Foetal growth retardation (a baby in the womb fails to grow at the expected rate during the pregnancy)
Gastrointestinal malformation
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Neutropenia (an abnormally low number of neutrophils)
Premature baby
Small for dates baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age)

2-9:

n/a

10-19:

Grand mal convulsion (a type of generalized seizure that affects the entire brain)

20-29:

n/a

30-39:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Nausea (feeling of having an urge to vomit)
Pneumonia fungal
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Rash
Activated partial thromboplastin time prolonged
Angiopathy (generic term for a disease of the blood vessels)
Duodenitis (inflammation of the duodenum)
Faeces discoloured

40-49:

Normochromic normocytic anaemia (forms of anaemia in which the average size and haemoglobin content of the red blood cells are within normal limits)
C-reactive protein increased
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Moyamoya disease (a disease in which certain arteries in the brain are constricted. blood flow is blocked by the constriction)
Abdominal pain
Anion gap increased
Blood amylase increased
Blood bicarbonate decreased
Depressed level of consciousness
Dyspnoea (difficult or laboured respiration)

50-59:

Abdominal distension
Ascites (accumulation of fluid in the abdominal cavity)
Atypical pneumonia (acute respiratory disease marked by high fever and coughing)
Breath sounds decreased
Cardiac murmur (an heart sound in valve abnormality)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatic failure (liver failure)
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Inflammation
Oedema peripheral (superficial swelling)

60+:

Anaemia (lack of blood)
Communication disorder (speech and language disorder)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Urinary retention (the inability to completely or partially empty the bladder)
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Neutropenia (an abnormally low number of neutrophils)
Neutropenic sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection)
Hallucination (an experience involving the perception of something not present)
Pruritus (severe itching of the skin)
Skin disorder (skin disease)

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 24.00%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 5 people, 20.00%
Rickets (softening of bones): 4 people, 16.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 4 people, 16.00%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 3 people, 12.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 12.00%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 3 people, 12.00%
Constipation: 3 people, 12.00%
Pain: 2 people, 8.00%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Ranitidine hydrochloride and Cotrim?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously