Ranitidine and Avandamet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Ranitidine (ranitidine) and Avandamet (metformin hydrochloride; rosiglitazone maleate). Common drug interactions include chronic kidney disease among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Ranitidine and Avandamet. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Ranitidine?

Ranitidine has active ingredients of ranitidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 234,475 Ranitidine users. Check the latest studies of Ranitidine.

What is Avandamet?

Avandamet has active ingredients of metformin hydrochloride; rosiglitazone maleate. It is often used in diabetes. eHealthMe is studying from 16,084 Avandamet users. Check the latest studies of Avandamet.

On Aug, 12, 2026

62 people who take Ranitidine and Avandamet together, and have interactions are studied.

Ranitidine and Avandamet drug interactions.

What are the common drug interactions of Ranitidine and Avandamet, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Abdominal distension
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Heart rate irregular
Pain
Vomiting
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

male:

Cardiac disorder
Circulatory collapse
Anaemia (lack of blood)
Diarrhoea
Blood cholesterol increased
Cardiac failure
Dizziness
Dyspnoea (difficult or laboured respiration)
Hypertriglyceridaemia (excess of triglycerides in the blood)
Arthralgia (joint pain)

What are the common drug interactions of Ranitidine and Avandamet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Suicidal ideation
Suicide attempt
Weight increased

40-49:

Cardiac disorder
Death
Circulatory collapse
Sick sinus syndrome (a collection of heart rhythm disorders)
Arthropathy
Chronic kidney disease
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Neuropathy peripheral (surface nerve damage)
Renal failure (kidney dysfunction)
Activated partial thromboplastin time prolonged

50-59:

Weight increased
Abdominal distension
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Vomiting
Alopecia (absence of hair from areas of the body)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deformity (disfigurement)
Nerve injury
Pulmonary embolism (blockage of the main artery of the lung)

60+:

Chest pain
Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)
Back pain
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Angina pectoris (chest pain due to ischemia of the heart muscle)
Arthralgia (joint pain)

What are the existing conditions these people have? *

Depression: 16 people, 25.81%
Stress And Anxiety: 7 people, 11.29%
Pain: 7 people, 11.29%
Insomnia (sleeplessness): 7 people, 11.29%
High Blood Pressure: 7 people, 11.29%
Nervousness: 6 people, 9.68%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 6.45%
High Blood Cholesterol: 4 people, 6.45%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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