Rapaflo and Guaifenesin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rapaflo (silodosin) and Guaifenesin (guaifenesin). Common drug interactions include chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Rapaflo and Guaifenesin. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Rapaflo?

Rapaflo has active ingredients of silodosin. It is often used in prostate examination abnormal. eHealthMe is studying from 3,929 Rapaflo users. Check the latest studies of Rapaflo.

What is Guaifenesin?

Guaifenesin has active ingredients of guaifenesin. It is often used in cough. eHealthMe is studying from 12,106 Guaifenesin users. Check the latest studies of Guaifenesin.



On Jul, 09, 2026

13 people who take Rapaflo and Guaifenesin together, and have interactions are studied.

Rapaflo and Guaifenesin drug interactions.

What are the common drug interactions of Rapaflo and Guaifenesin, by gender? *:

female:

n/a

male:

  1. Chronic kidney disease
  2. Dizziness
  3. Paranasal sinus discomfort
  4. Rash pruritic (redness with itching)
  5. Renal injury (kidney injury)
  6. Respiratory tract infection
  7. Skin cancer
  8. Trismus (reduced opening of the jaws)
  9. Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
  10. Pneumonia

What are the common drug interactions of Rapaflo and Guaifenesin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Pneumonia
  2. Pulmonary embolism (blockage of the main artery of the lung)

60+:

  1. Chronic kidney disease
  2. Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
  3. Paranasal sinus discomfort
  4. Rash pruritic (redness with itching)
  5. Renal injury (kidney injury)
  6. Respiratory tract infection
  7. Skin cancer
  8. Trismus (reduced opening of the jaws)
  9. Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
  10. Cardiac failure

What are the existing conditions these people have? *

  1. Pain: 4 people, 30.77%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 30.77%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 23.08%
  4. Embolism (obstruction of an artery, typically by a clot of blood or an air bubble): 2 people, 15.38%
  5. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 15.38%
  6. Multiple Myeloma (cancer of the plasma cells): 2 people, 15.38%
  7. Lymphoma (cancer that begins in immune system cells): 2 people, 15.38%
  8. High Blood Pressure: 2 people, 15.38%
  9. Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 15.38%
  10. Urinary Incontinence (inability to control the flow of urine and involuntary urination): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Rapaflo and Guaifenesin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Rapaflo and Guaifenesin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rapaflo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Guaifenesin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rapaflo and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Guaifenesin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on silodosin and guaifenesin (the active ingredients of Rapaflo and Guaifenesin, respectively), and Rapaflo and Guaifenesin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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