Rapaflo and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rapaflo (silodosin) and Protonix (pantoprazole sodium). Common drug interactions include hyperparathyroidism secondary among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Rapaflo and Protonix. It is created by eHealthMe based on reports of 100 people who take the same drugs from the FDA, and is updated regularly.

What is Rapaflo?

Rapaflo has active ingredients of silodosin. It is often used in prostate examination abnormal. eHealthMe is studying from 3,929 Rapaflo users. Check the latest studies of Rapaflo.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

On Jul, 20, 2026

100 people who take Rapaflo and Protonix together, and have interactions are studied.

What are the common drug interactions of Rapaflo and Protonix, by gender? *:

female:

Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Blood glucose decreased
Cough
Drug eruption (adverse drug reaction of the skin)
Dysgeusia (disorder of the sense of taste)
Fibromyalgia (a long-term condition which causes pain all over the body)
Headache (pain in head)
Overdose
Psoriasis (immune-mediated disease that affects the skin)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Nephrogenic anaemia (anaemia due to kidney disease)
Anxiety
Diarrhoea
Dizziness
Rectal haemorrhage (bleeding from anus)
Vomiting
Constipation
Abdominal pain

What are the common drug interactions of Rapaflo and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Angioedema (rapid swelling of the dermis)
Asthma
Fall
Hypersensitivity
Loss of consciousness
Memory impairment

50-59:

Skin ulcer
Stasis dermatitis (skin inflammation caused by blood pooling in the veins in your legs)
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Suicidal ideation
Anaphylactic reaction (serious allergic reaction)
Cardiomyopathy (weakening of the heart muscle)
Confusional state
Plasma cell myeloma (cancer that begins in plasma cells)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Disease progression
Fall
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight decreased
Renal impairment (severely reduced kidney function)
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)

What are the existing conditions these people have? *

Pain: 17 people, 17.00%
Multiple Myeloma (cancer of the plasma cells): 15 people, 15.00%
High Blood Pressure: 13 people, 13.00%
High Blood Cholesterol: 7 people, 7.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 7.00%
Immunodeficiency Common Variable: 6 people, 6.00%
Dehydration (dryness resulting from the removal of water): 6 people, 6.00%
Stress And Anxiety: 5 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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