Rapamune and Actonel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rapamune (sirolimus) and Actonel (risedronate sodium). Common drug interactions include lymphoedema among females and blood creatinine increased among males.

The phase IV clinical study analyzes what interactions people have when they take Rapamune and Actonel. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

What is Actonel?

Actonel has active ingredients of risedronate sodium. It is often used in osteoporosis. eHealthMe is studying from 29,369 Actonel users. Check the latest studies of Actonel.

On Jul, 20, 2026

34 people who take Rapamune and Actonel together, and have interactions are studied.

What are the common drug interactions of Rapamune and Actonel, by gender? *:

female:

Lymphoedema (localized fluid retention and tissue swelling)
Oedema peripheral (superficial swelling)
Diarrhoea
Hepatic enzyme increased
Kidney transplant rejection
Pyelonephritis acute (sudden inflammation of kidney caused by bacteria)
Vomiting
Arthralgia (joint pain)
Cardiac arrest
Complications of transplanted kidney

male:

Blood creatinine increased
Enteritis (inflammation of the small intestine)
Laryngitis fungal (inflammation of the larynx due to fungal infection)
Lymphocele (a collection of lymphatic fluid within the body not bordered by epithelial lining)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oesophageal candidiasis (fungal infection of oesophagus)
Pneumonia
Ureteric stenosis (abnormal narrowing or contraction of a duct or canal)
Wound dehiscence (a surgical incision reopens either internally or externally)
Abdominal pain

What are the common drug interactions of Rapamune and Actonel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Enteritis (inflammation of the small intestine)
Death
Vasculitis (inflammation of a blood vessel or blood vessels)
Cardiac arrest
Heart transplant rejection

30-39:

Cardiac arrest
Clostridial infection (infectious conditions by clostridium bacteria)
Colitis (inflammation of colon)
Electrocardiogram st segment depression
Gastroenteritis (inflammation of stomach and intestine)
Injection site erythema (redness at injection site)
Plasmacytoma (neoplasm of plasma cells (usually in bone marrow))
Rash
Staphylococcal infection (an infection with staphylococcus bacteria)
Transplant rejection (a transplant material is not worked)

40-49:

Pyelonephritis acute (sudden inflammation of kidney caused by bacteria)
Peliosis hepatis (randomly distributed multiple blood-filled cavities throughout the liver)

50-59:

Interstitial lung disease
Venous thrombosis (blood clot (thrombus) that forms within a vein)
Complications of transplanted kidney
Diarrhoea
Gastroenteritis (inflammation of stomach and intestine)
Hypokalaemia (low potassium)
Immunosuppressant drug level increased
Kidney transplant rejection
Renal impairment (severely reduced kidney function)
Vomiting

60+:

Blood creatinine increased
Abdominal hernia
Lymphocele (a collection of lymphatic fluid within the body not bordered by epithelial lining)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oesophageal candidiasis (fungal infection of oesophagus)
Pneumonia
Ureteric stenosis (abnormal narrowing or contraction of a duct or canal)
Wound dehiscence (a surgical incision reopens either internally or externally)
Abdominal pain
Blood potassium increased

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 8.82%
High Blood Pressure: 3 people, 8.82%
Dyslipidaemia (abnormal amount of lipids): 3 people, 8.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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