Rapamune and Digoxin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rapamune (sirolimus) and Digoxin (digoxin). Common drug interactions include anhedonia among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Rapamune and Digoxin. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

What is Digoxin?

Digoxin has active ingredients of digoxin. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 93,740 Digoxin users. Check the latest studies of Digoxin.

On Aug, 01, 2026

91 people who take Rapamune and Digoxin together, and have interactions are studied.

What are the common drug interactions of Rapamune and Digoxin, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cardiac failure
Cerebral infarction (less blood supply to brain resulting tissue damage)
Depression
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fear
Injury
Multi-organ failure (multisystem organ failure)

male:

Drug ineffective
General physical health deterioration (weak health status)
Hypertension (high blood pressure)
Pain
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Anaemia (lack of blood)
Dementia (madness)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)

What are the common drug interactions of Rapamune and Digoxin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Operative haemorrhage (bleeding due to surgery)

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Death
Depression
Emotional distress
Fear
Injury
Multi-organ failure (multisystem organ failure)
Pain
Renal failure (kidney dysfunction)

30-39:

Acute respiratory distress syndrome
Blood creatinine increased
Candidal infection (fungal infection)
Cardiomegaly (increased size of heart than normal)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Haemoglobin s decreased
Multi-organ failure (multisystem organ failure)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Neutrophilia
Pallor

40-49:

Cardiac failure
Cardiomegaly (increased size of heart than normal)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Muscle weakness (a lack of muscle strength)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)
Pneumonia
Post procedural haemorrhage (post procedural bleeding)
Pulmonary haemorrhage (acute bleeding from the lung)
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory failure (excl neonatal) (inadequate gas exchange by the respiratory system(excluding neonatal))

50-59:

Erythema (redness of the skin)
General physical health deterioration (weak health status)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Scar

60+:

Drug ineffective
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Nausea (feeling of having an urge to vomit)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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